What are the commonly used equipment in cosmetic production purification workshop?

Cosmetics production workshop mainly involves the crushing and grinding of raw materials, mixing, emulsification and dispersion of materials, transportation, heating, sterilization of materials, molding and packaging of products, and purification of cosmetic water in the preparation process. Commonly used equipment mainly includes paste...
Text label: Cosmetics production purification workshop, dust-free workshop design and installation, common equipment

What are the commonly used equipment in cosmetic production purification pharmaceutical cleanroom?


Cosmetics production workshop mainly involves the crushing and grinding of raw materials, mixing, emulsification and dispersion of materials, transportation, heating, sterilization of materials, molding and packaging of products, and purification of cosmetic water in the preparation process. Commonly used equipment mainly includes emulsification equipment for cream dairy products, mixing and degassing equipment after emulsification, and auxiliary purification equipment, sterilization equipment and filling equipment. The key step to ensure quality in the production of cream cosmetics is emulsification, so emulsification equipment is an important equipment; according to the differences in emulsification equipment and process differences, mechanical methods are divided into tubular method, jet method, stirring method, homogenization method, etc. , among which the stirring method and the homogenizing method are the two most commonly used methods in the cosmetic industry.
. Generally, agitation and emulsification can obtain an emulsion with a particle size of 5-10 μm. The quality of cosmetics, high-efficiency homogeneous emulsification equipment with stronger dispersing ability is adopted. Stirring and emulsification equipment is generally used to process low-viscosity or medium-viscosity liquids. The types of stirring and emulsification equipment are: vertical stirring tank, horizontal stirring tank, eccentric stirring equipment, and mobile stirring equipment.


In the production process of cosmetics, the homogenizer is usually used in combination with a stirrer to achieve high stability of paste and emulsion and high fineness of particles; commonly used homogenizing and emulsification equipment includes shearing homogenizer, high pressure homogenizer machine, colloid mill, ultrasonic emulsifier, centrifugal homogenizer, etc. The essence of the homogenization of these equipment is to make the dispersed substances in the feed liquid, including solid particles, droplets, etc., broken by the shearing action of fluid mechanics ; According to the type of energy used and the characteristics of the structure, the homogenizer can be divided into two categories: rotary type and pressure type. The rotary type homogenizer is composed of a rotor or a rotor-stator system, which directly transmits mechanical energy to the liquid medium to be processed; pressure; This type of homogenizing equipment can enable the liquid medium to obtain high-pressure energy, which can convert the high-pressure energy into kinetic energy when the liquid passes through the homogenizing mechanism, thereby obtaining fluid force. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for cosmetic production purification workshops and dust-free workshops.














The high-pressure homogenizer in the cosmetic production workshop is a high-pressure pump, which uses high pressure to make the liquid material flow through the narrow gap at high speed and is subjected to strong shearing force, the impact force generated by the impact of the liquid material on the metal ring, and the static pressure The combined action of the cavities generated by the sudden drop and sudden rise can disperse the emulsion or suspension with larger particles into a stable emulsion or suspension with fine particles. The refining effect of the high-pressure homogenizer is stronger; the refining effect of the homogenizer utilizes the interaction between the materials, so the calorific value of the material is small, so the performance of the material can be kept basically unchanged; the easy damage of the homogenizer There are many parts, and the maintenance workload is large, especially in the case of high pressure; the homogenizer can transport materials quantitatively, because it relies on the reciprocating pump to feed the material, and the energy consumption is large; the homogenizer is not suitable for high viscosity. .
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Layout of Class B area of u200bu200bpreparation gmp purification workshop
The air purification system methods for realizing static non-unidirectional flow level 5 and dynamic non-unidirectional flow level 7 in the B-level area of u200bu200bthe preparation gmp purification workshop can be as follows.
(1) Dual-system air supply mode
When the dynamic and static ventilation times differ greatly, two systems can be set up according to dynamic and static...
Text label: gmp purification pharmaceutical cleanroom layout, preparation workshop B-level area layout

The layout of the B-level area of u200bu200bthe preparation gmp purification workshop


The air purification system methods for realizing static non-unidirectional flow level 5 and dynamic non-unidirectional flow level 7 in the B-level area of u200bu200bthe preparation gmp purification workshop can be as follows.


(1) Dual-system air supply mode


When the dynamic and static ventilation times differ greatly, two systems can be divided according to dynamic and static:


One system runs under the dynamic ventilation rate, with fresh air, return air, and air conditioning equipment in the system.


The other system also operates under the static ventilation rate, only the indoor self-circulation, the ventilation rate is selected according to the static ventilation rate and the dynamic ventilation rate. There is no air conditioner in the system.


There are fewer tuyere when it is dynamic, and more tuyere when it is static.


(2) Single-system air supply mode


The system and air outlet are designed according to the static air exchange rate. Through frequency conversion, the air volume can be adjusted down when dynamic.






(3) Single-system air supply and self-purifier method


①Cabinet-type self-purifier is installed in the passage behind the wall panel, with air supply on the upper side and return air on the same side.


②Cabinet-type self-purifiers are installed indoors.


③Any self-purifiers should be placed indoors according to possible positions.


Air outlet arrangement


The different structural forms of the A-level area will affect the arrangement of the tuyere in the B-level area.


(1) The A-level area is basically completely closed to the ground.


In this case, the airflow from area A is basically short-circuited by the return air outlet of area B, so the contribution of airflow from area A to area B can be ignored, which can be regarded as an increased safety factor, and area B can still refer to the previous introduction The calculation of the knowledge of the air volume of the system determines and arranges the air supply outlets, so that the air volume in the B area can be adjusted.


(2) The situation where the A-level area is fully open.


From the calculation of the system air volume knowledge introduced before, it can be seen that when the area B is calculated according to the uniform distribution, nu003d119 times/h, because the filter is not arranged in the B area, the uneven distribution system ψ cannot be calculated according to the method of the introduced system air volume knowledge, And if selected, ψu003d0.86, that is to say, there should be at least 0.86X119u003d102 times/h.






If the air supply speed of area A is considered as 0.45m/s, when the air supply volume of area A can meet the needs of 99.8 times/h, the ratio of area ym2 of area A to the area of u200bu200bthe whole room xm2 is (assuming the room height is 2.8m) ):


y/xu003d(2.8×102)/(0.45X3600)u003d0.176


That is, the area of u200bu200barea A can reach 1/6 of the total room area, and area B can reach static level 5. Since the actual situation is very complicated (including various factors such as air supply speed, floor level, etc.), we cannot be bound by this number.
As with the previous discussion of airflow organization, considering the safety factor, this ratio is generally 1/5. This percentage figure just shows that, under the condition that there is a certain area in area A, the air is supplied without enclosures, and there is no air outlet in area B, it is expected to reach level 5.


(Note: Reference articles for calculation knowledge such as air volume and airflow organization:


Local one-way flow and air outlet in sterile clean room: http://www.ccg-sz.com/xinwendongtai/32-902.html


(3) Self-circulation in area A or self-circulation plus return air in area B.


If all self-circulation in area A, or there is return air in area B but the return air volume is much smaller than the self-circulating air volume, then all or most of the return air in area B is return air in area A, and the cleanliness of return air is obviously higher than that in '2' Air supply cleanliness is poor. Therefore, when there is no air supply in zone B, the ratio of zone A to the total room area is greater than the ratio in '2hongjing Global Purification can provide supporting services such as consultation, planning, design, construction, installation and transformation of purification workshops and GMP workshops.


(4) The A-level area is above the working face and is completely closed to the top.


Let the enclosure be 40cm away from the table at this time, or 40cm away from the section of the work area to be detected. Because the sampling is generally carried out at the section of the working area about 80cm above the ground, the airflow in area A at this time can basically cover the height of the working surface in area B, but after all, there will be more eddy currents in the upper part of area B. The air supply outlet should be set up in the area according to the principle of '1'. Even if the area A has self-circulation, it should only be regarded as a safety factor.
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Preparation of purified water in GMP pharmaceutical cleanroom

The raw water pretreatment device in GMP workshop is generally composed of raw water pump, multi-media filter, activated carbon filter, precision filter and water softener; the multi-media filter is mostly filled with quartz sand, etc., mainly through mechanical filtration and adsorption. , to remove solid impurities such as suspended solids in water...
Text label: GMP workshop design, GMP workshop engineering company, purified water preparation

Preparation of purified water in GMP workshop


The raw water pretreatment device in GMP pharmaceutical cleanroom is generally composed of raw water pump, multi-media filter, activated carbon filter, precision filter and water softener; the multi-media filter is mostly filled with quartz sand, etc., mainly through mechanical filtration and adsorption. , remove suspended solids and other solid impurities in the water, reduce the turbidity of the water, and the bacteria and organic matter in the water can also be removed in large quantities with the reduction of the turbidity; the activated carbon filter has a strong physical adsorption capacity, which can effectively adsorb water. The impurities, especially organics and microorganisms, also have a good adsorption effect on the residual chlorine in the water; the function of the precision filter is to intercept all substances with a particle size larger than 5 μm to meet the influent requirements of electrodialysis, reverse osmosis and particle exchange. ; Ion exchange is one of the basic methods of raw water treatment. The ion exchange resin is used to remove the yin and yang particles in the dissolved salts, minerals and dissolved gases in the water. The advantage of ion exchange treatment of raw water is that all water has high chemical purity, The equipment is simple, the fuel and cooling water are saved, and the cost is low, but the microorganisms and personnel are not easy to remove, and the ion exchange resin needs to be regenerated or replaced regularly.


Reverse osmosis is a membrane separation operation that uses pressure difference as the driving force to remove dissolved salts in water by using a semi-permeable membrane; the semi-permeable membranes commonly used in reverse osmosis include cellulose acetate membrane and polyamide membrane, generally a The first-stage reverse osmosis device can remove 90%-95% of monovalent ions, 98%-99% of divalent ions, and can also remove microorganisms; the structure of reverse osmosis device is the same as that of general microporous membrane The pressure is generally 2.5-7MPa, so the structural requirements are high; due to the low rate of water permeation through the membrane, the membrane area per unit volume in the reverse osmosis device is generally larger, so the reverse osmosis devices used in the industry are mostly spiral. Coiled and hollow fiber structures. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for GMP workshops and sterile workshops.













Distillation is the most classic and reliable method for preparing water for injection. Distillation removes various volatile and non-volatile substances by repeating the evaporation and condensation process, including heat pumps, inorganic salts, organic salts, soluble polymer materials, etc.; The quality of the obtained water for injection is closely related to the water source, the treatment of the raw water, the material structure of the distiller and the storage of the water. A part of the first distilled water is properly discarded, and it can be formally collected after the inspection is passed. When collecting, care should be taken to prevent dust and other dirt from falling into it. It is best to use a collection system with a sterile filter device, and seal it at above 80 °C or after sterilization. save.
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