Washing of clean room containers

by:PHARMA     2022-06-23
Washing of clean room containers


The washing methods of ampoules in dust-free workshops generally include water washing method, pressurized jet air-water washing method and continuous rotary ultrasonic cleaning method; The water is thrown out with a water shaker, and it is generally repeated three times to achieve the purpose of cleaning. This method of washing...
Text label: clean room design and installation, clean room engineering, container washing

Washing of containers in clean room


The washing methods of ampoules in dust-free workshops generally include water washing method, pressurized jet air-water washing method and continuous rotary ultrasonic cleaning method; The water is thrown out with a water shaker, which is usually repeated three times to achieve the purpose of cleaning. The cleanliness of the ampoule washing by this method can generally meet the requirements, with high production efficiency and low labor intensity, but the washing quality is not as good as that of the pressurized jet air-water washing method. Ampoules under 5ML. Pressurized jet air-water washing method, this method is considered to be an effective bottle washing method in current production, especially suitable for the washing of large ampoules, using filtered distilled water and filtered compressed air to spray into the ampoules alternately by needle for jet washing , the pressure of the compressed air is generally 294.2-392.3KPa, the flushing sequence is air-water-air-water-air, generally 4-8 times, the filtration of washing water and air in this method is the key, the compressed air is first cooled, The pressure is balanced by the air storage cylinder, and then filtered and purified by coke, foam plastic, porcelain ring or sand rod.


Continuous rotary ultrasonic cleaning method is a cleaning method that combines pressurized jet air-water cleaning and ultrasonic cleaning. First, the ampoule is pressurized and filled with circulating water, and then transferred to a 60-70°C chamber filled with sterilized distilled water. Ultrasonic cleaning is performed in the water tank, then the ampoules are rinsed upside down with circulating water three times, air blown once, and finally inverted with fresh distilled water and air blown. Only clean air purging is used, but the ampoules should be strictly prevented from contamination when they are produced in the glass factory. When washing, first send the glass bottles to the bottle unscrambler, arrange them in order, and enter the bottle brush machine one by one by the conveyor belt. Two rows of rotating brushes are erected on both sides of the conveyor belt to make the bottles advance on the conveyor belt. Rotate, and at the same time, use the water above the conveyor belt to wash the bottle body, and the outer brushed bottle will be brought into the inner bottle brush machine through the conveyor belt to complete the washing operation. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for dust-free workshops and sterile workshops.














After cleaning the ampoules in the dust-free pharmaceutical cleanroom, they should generally be dried in an oven at a temperature of 120-140℃. Before aseptic operation or low temperature sterilization, the ampoules should be sterilized by dry heat at a temperature above 150℃ for 1H. The above; a tunnel-type electric heating oven is mostly used in mass production. The oven is composed of a conveyor belt, a heater, a laminar flow box, a heat insulation frame, etc.; To make full use of heat energy, the hot and humid air in the drying area in the middle section of the oven is discharged out of the oven through the special air, but the drying area should maintain positive pressure and be supplemented by a class A purifier if necessary. Tunnel heating is divided into three areas: preheating section, middle section and cooling section. The temperature in the preheating section is from room temperature to 100 °C, where most of the water in the ampoule evaporates; the middle section is a high-temperature drying and sterilization area, with a temperature of 300-450 ℃, kill bacteria and pyrogens, and remove residual moisture; the cooling zone is lowered from high temperature to about 100 ℃, and then the ampoule leaves the tunnel to realize continuous production of ampoule drying and sterilization; a forced ventilation system is set at the top of the tunnel to discharge hot and humid air in time. In order to prevent pollution, a local laminar flow device can be attached, and the storage time of sterilized empty ampoules should not exceed 24H.
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