Requirements for granule clean workshop
Clean workshop granules can be divided into soluble granules, suspended granules, effervescent granules, enteric-coated granules, slow-release granules and controlled-release granules. The hygroscopicity is small, and it is more convenient to take. When necessary, it can be coated, ...
Text label: clean workshop design, clean workshop construction, granule clean workshop

Requirements for granule clean workshop


Clean workshop granules can be divided into soluble granules, suspended granules, effervescent granules, enteric-coated granules, slow-release granules and controlled-release granules. The hygroscopicity is relatively small, and it is more convenient to take. Coating can be carried out if necessary. However, the mixture of various particles may cause inaccurate dose due to uneven particle size or large difference in density; The required materials, and check the product name, batch number, quantity, and specifications; enter the granulation room, check whether there is a 'clearance certificate' of the last production, and have the signature of the quality inspector or inspector; check whether the granulation room is clean and whether there is any Leftover items unrelated to production; check that the equipment is clean and intact, and has a 'cleaned' sign; check whether the air inlet and return air outlet of the operation clean room modular are normal; check whether the measuring instrument is consistent with the weighing range, whether it is clean and intact, whether there is any Certificate of conformity, and within the validity period of use; check the record table, clean, and whether there is a production record sheet of the previous batch; check whether the temperature, relative humidity, and pressure difference in the operation room meet the requirements, and record it; check the turnover container used And whether the production equipment is clean and damaged.


Put out the raw material container and add the material, fasten the filter bag to the bag filter frame, and check whether the filter bag is cracked and small holes, and repair the seam if necessary; remove the spray gun hole cover on the spray chamber The oil hole should be aligned, the nozzle should be perpendicular to the bottom of the raw material container, and the nut should be tightened; the compressed air pipe and the infusion pipe should be connected. Turn on the spray switch. At this time, compressed air is sprayed from the nozzle. After 2 seconds, turn on the adjustment switch of the liquid pump to spray the liquid. Adjust the pressure of the compressed air to 2kgf/cm2. Check whether the atomization state of the spray gun is normal and whether there is leakage. Confirm After the spray gun is atomized normally, stop the liquid pump, and then stop spraying the liquid; after the liquid delivery stops for 2 seconds, the compressed air also stops spraying, and after a few seconds, check whether there are droplets in the nozzle, and if so, check the sealing of each sealing ring in the spray gun Whether it is reliable; the size of the droplet diameter can be realized by changing the nozzle and adjusting the knob at the rear. At the same time, the size of the droplet can be changed by adjusting the compressed air pressure. The higher the pressure, the smaller the droplet, and vice versa. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for clean workshops and sterile workshops.














When the material is preheated to 50°C, turn on the liquid pump, spray and granulate, and check the preparation of the particles from the observation port. When the adhesive liquid is sprayed, a little warm water should be added to spray. The spray gun and the infusion tube are cleaned at the same time, which can avoid the blocking phenomenon of the spray gun when it is used for the second time. Boiling granulation and inspection before equipment operation, equipment status inspection, auxiliary equipment inspection, instrument inspection; during granulation, the setting and Adjustment; the filter bag should be removed and cleaned every shift, otherwise it will cause blockage due to excessive accumulation in the bag, which will affect the establishment of fluidization and the efficiency of granulation. When changing varieties, the host should be cleaned.
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How to perform electrostatic testing in a clean room workshop?

The purpose of the electrostatic test is to determine the benchmark of electrostatic charge potential, surface resistance characteristics, and the effectiveness of the ionizer charge neutralization system; the test consists of 4 parts: electrostatic charge potential measurement, surface resistance test, ionizer discharge time test, Ionizer residual voltage measurement;...
Text label: clean clean room modular electrostatic testing, clean clean room modular testing and testing

How to conduct electrostatic testing in clean clean room modular workshop?


The purpose of the electrostatic test is to determine the benchmark of electrostatic charge potential, surface resistance characteristics, and the effectiveness of the ionizer charge neutralization system; the test consists of 4 parts: electrostatic charge potential measurement, surface resistance test, ionizer discharge time test, Ionizer residual voltage measurement; electrostatic charge potential measurement to determine the electrostatic charge potential generated on objects in the test area, which is achieved by measuring the surface voltage or electric field generated by the charge, and surface resistance testing to determine whether the object can be effectively dissipated when grounded Static charge, it also determines whether it is grounded, and by measuring surface resistance and surface-to-ground resistance, electrostatic dissipation characteristics can be assessed. Ionizer discharge time tests are related to the ionizer residual voltage measurement and are related to the performance of the ionizer, which is used to neutralize the surface charge of an ungrounded or insulator, these tests are performed to measure the discharge time of an initially charged isolated metal plate, As well as determining the residual voltage of the initially uncharged isolated metal plate, the results of each measurement indicate the efficiency of neutralizing electrostatic charges and the resulting imbalance between positive and negative ions.


Surface resistance measurement, place two electrodes on the surface with the correct spacing, measure the surface resistance with an ohmmeter with a suitable output voltage, the ohmmeter must be able to measure at 10V and 100V, record each specified measurement point The measured value of ; ground one electrode and the other electrode should be placed on the surface as recommended by the manufacturer, measure the surface resistance with an ohmmeter with a suitable voltage output, and record the measured value at each specified measuring point. Ionizer test: The performance of the ionizer is evaluated by measuring the discharge time and residual voltage. The imbalance of positive and negative ions in the ionized air flow is measured by the residual voltage measurement. The efficiency of the ionizer to eliminate static charge is measured by It is determined by the discharge time; the instrument for measuring the performance of the ionizer specified in the industry standard is a charged plate detector, which basically consists of an isolated conductive plate of known capacitance, which is charged to a known voltage or to zero Power supply, a means of measuring the voltage on the board and the time it takes to reach a preset level; place the CPM at the specified measurement point, and use the power supply to charge the isolated conductive plate to a known positive voltage; as the static charge on the board is When the ionizer is reduced, measure the time when the static voltage on the plate will reach 10% of the initial voltage, record the measurement value at each specified measurement point; charge the plate to a known negative voltage, record the measurement at each specified measurement point value. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for clean rooms and purification workshops.














Clean room surface charge potential measurement: choose the test instrument according to whether the object to be measured is an insulator or a conductor and its physical size, the hand-held instrument probe, the distance from the grounded metal plate according to the manufacturer's regulations, the electrometer or field strength Set the reading of the meter to zero; hold the probe so that it is parallel to the metal plate, the surface area of u200bu200bthe metal plate should be large enough for the required probe opening, and the metal plate is large enough to have a suitable probe to surface spacing ratio; make the probe close to the surface of the object, and use an electrometer to measure the surface voltage of the conductor, or use an electrostatic field strength meter to measure the electric field of an insulator or conductor, and record the measured value of each specified measuring point. Residual voltage measurement: Place the CPM at the specified measurement point, ground the isolated conductive plate to remove residual charge, if necessary to zero the CPM reading, disconnect the ground connection; allow sufficient time for the isolated metal plate to drain from the ionizer Once the charge is obtained and the reading is stable, record the residual voltage. Some ionizers will jump from positive to negative during normal operation. In this case, record the maximum positive and maximum negative readings of the residual voltage.
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Dust-free pharmaceutical cleanroom workshop drying equipment

Drying is the operation of using heat energy to vaporize the moisture in wet materials, and using airflow or vacuum to take away the vaporized moisture to obtain dry solid products. The divided airflow is generally air; the purpose of the drying operation is to remove some solids...
Text label: clean room workshop, drying equipment, Zhongjing Global Purification

Dust-free pharmaceutical cleanroom pharmaceutical cleanroom drying equipment


Drying is the operation of using heat energy to vaporize the moisture in wet materials, and using airflow or vacuum to take away the vaporized moisture to obtain dry solid products. The divided air flow is generally air; the purpose of the drying operation is to remove the moisture or solvent in some solid raw materials, semi-finished products and finished products, so as to facilitate storage, transportation, processing and use; the convection dryer is the direct contact of the hot gas in a convection manner Drying equipment for mass transfer and heat transfer between the materials. The chamber dryer mainly uses hot air to pass through the wet material surface to achieve the purpose of drying; its structure is simple, the equipment investment is low, and the adaptability is strong. , sometimes used for drying more expensive materials; the disadvantage is that it often requires manual turning of materials, high labor intensity, poor conditions, uneven drying, low heat utilization rate, suitable for small-scale and multi-variety, requiring large changes in drying conditions and long drying time. Wait for drying operation.


Air drying is to use high-speed hot air to blow powder and granular materials to suspend them in the drying tube, and dry them in the process of air conveying. It is a specific application of air conveying technology in drying; the length of air drying tubes is generally At 10-20m, when the operation is normal, the material stays in the drying tube for a short time, generally 0.5-2s, and no more than 5s at most. Air-flow drying has high production intensity, short drying time, wide adaptability, high heat utilization rate, simple structure, low cost, small footprint, continuous and stable operation, and easy control, so it is especially suitable for drying heat-sensitive materials; the disadvantage is that it is inconvenient to install and maintain , Most of the products obtained are fine powders, which are difficult to recover and separate, and are not suitable for materials that stick to walls, require a certain shape, and require drying below the critical moisture content. Several improved airflow dryers: multistage airflow dryer, pulse airflow dryer, cyclone airflow dryer. The cyclone air path dryer uses a cyclone separator as the drying tube. It has a cylindrical body with a slight taper, which is mostly made of stainless steel. The inner wall is smooth and non-sticky. It makes a spiral motion between the central exhaust pipe and the cylinder body, the dry material is discharged through the discharge port at the bottom of the cylinder, and the air is discharged from the central exhaust pipe. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for dust-free workshops and clean workshops.














Spray dryer is a convection dryer in which the material liquid is sprayed into mist droplets by the atomizer and dispersed in the hot air flow to quickly evaporate the moisture; the compressed air is filtered and sterilized by a filter, and then heated by a heater to make the The temperature and cleanliness meet the process requirements, the hot air enters the top of the spray tower, and the thin material liquid is sprayed into fine mist particles through the nozzle to fully contact the hot air for drying; the diameter of the droplets after atomization is 10-60μm, and the specific surface area is violent. The water evaporates very quickly. Before the droplets reach the wall of the device, they are dried into powder and fall into the bottom of the tower along the wall. The waste gas passes through the cyclone separator and the bag filter to collect the fine powder and then discharge. The spray dryer can directly obtain powder products from the liquid material, and has good solubility; short drying time and high quality; especially suitable for drying heat-sensitive materials; stable operation, easy automatic control, and reduced labor intensity. The disadvantage is that the volume heat transfer coefficient is small and the heat utilization rate is low; the equipment is bulky and the operation elasticity is small; the phenomenon of sticking to the wall is easy to occur;
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The ceiling is used in the decoration and construction stage of the clean room, but the selection of the ceiling is more stringent. The general ceiling is completely unsuitable for the clean room. So what material is used for the decoration of the clean room? Let sz-pharma answer this question for you. 1. What material is used for the ceiling of the dust-free workshop? Most of the ceiling materials used for the decoration of the dust-free pharmaceutical cleanroom are materials with smooth surfaces, such as color steel plates, plastic plates, aluminum plates, and gussets. The surface can be wiped with a dust-free rag with strong adsorption, and it can be used with tools such as telescopic rods and tiger clips, which is handy. Ultrafiltration dust industrial vacuum cleaner can be used to vacuum the uneven places and inner corners. 1. The unique feature of the aluminum-magnesium alloy ceiling is that it has good oxidation resistance. At the same time, due to the addition of an appropriate amount of manganese, the strength and rigidity are significantly improved. It is an excellent material for the ceiling of the clean room. . 2. The only bad thing about this type of ceiling is that the oxidation resistance is slightly worse than that of the aluminum-magnesium alloy ceiling. However, the strength and stiffness of the aluminum-manganese alloy ceiling are slightly better than those of the aluminum-magnesium alloy, and it is also a relatively good one. Dust-free workshop ceiling material. 3. Aluminum alloy ceiling The aluminum alloy ceiling contains less manganese and magnesium, and its strength and rigidity are even more difficult to compare with the aluminum-magnesium alloy ceiling and the aluminum-manganese alloy ceiling. Even the anti-oxidation ability is very general, and the purification level is higher. The production workshop is not suitable for choosing aluminum alloy ceiling. In addition to requiring the clean room ceiling to have strong oxidation resistance and excellent strength and stiffness, the clean room ceiling must also have excellent rust resistance and waterproof ability, otherwise it cannot be used in the clean room. 2. Attention should be paid to accidents in the decoration of the ceiling in the dust-free workshop 1. The inspection batch of the ceiling project should be divided into an inspection batch according to the area of ​​500 of the clean room (area), and it should also be divided into an inspection batch if it is less than 500. 2. Before installing the keel, the process handover procedures should be completed according to the design requirements for the clear height of the room, the elevation of the opening, and the elevation of the pipes, pharma machinery and other supports in the ceiling. 3. The embedded parts, steel suspenders and section steel suspenders in the ceiling project should be treated with anti-rust or anti-corrosion treatment; when the upper part of the ceiling is used as a static pressure box, the connection between the embedded parts and the floor or wall should be sealed. deal with. The support and hanger should be dust-proof. 4. The fixing and hanging parts of the ceiling should be connected with the main structure. It shall not be connected with pharma machinery supports and pipeline supports; the hanging parts of the ceiling shall not be used as pipeline supports and hangers or pharma machinery supports and hangers. 5. Air filters, lamps, smoke detectors, speakers and all kinds of pipelines should be smooth, tight and clean around the openings where they pass through the ceiling, and they should be sealed with non-combustible sealing materials. The perimeter of the maintenance opening of the concealed project shall be sealed with a gasket. 6. The elevation, size, arching, and gap between the panels of the ceiling should meet the design requirements. The gap between the boards should be consistent, and the gap error between each board should not be greater than 0.5; it should be evenly sealed with sealant, so that it is flat, smooth, slightly lower than the board surface, and there should be no interruptions and impurities. 7. The materials, varieties, specifications, etc. of the ceiling finish should meet the design requirements, and the product performance should be checked. 8. The installation of boom, keel and decorative panel must be safe and firm. 9. The material, specification, installation distance and connection method of the boom and keel shall meet the design requirements. The metal boom and keel should be treated with anti-corrosion on the surface. 10. The distance between the boom and the end of the main keel should not be greater than 300. When it is greater than 300, the boom should be added. The distance between the booms should be less than 1.5m. 11. The surface of the ceiling veneer should be clean, smooth, consistent in color, free from warping, cracks and defects; no mildew or dust. 12. The joints of metal suspenders and keels should be uniform, the corner seams should match, and the surface should be flat without warping and hammer marks. The allowable deviation and inspection method for the installation of the ceiling project shall comply with the following regulations.
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As a kind of composite board, the purification board has a high usage rate in the decoration and purification project of the clean workshop. Today, we will learn about some of the careful thinking of this product in the design of the decoration and purification engineering of the clean workshop, and look forward to your attention. 1. Due to its unique appearance, the purification board can be matched with glass plates and other things during the design to increase the aesthetics of the space; 2. It can add other materials to form new materials and increase the types of curtain walls in application; 3 , Under the condition of ensuring its stable performance, the wall of the product can be designed with some exaggerated appearances to meet the needs of modern life; 4. Its colors can be diversified, and designers can combine local Culture, outline patterns of different styles, and use it to express history and modernity. These ideas can be made into plates and achieve the desired effect. To sum up, in addition to the familiar basic functions of the purification board, the sz-pharma engineering designers also spent a lot of ingenuity on it when designing the product, which will make the product more popular with the younger generation. The future development trend will be better and better, so you can buy such unique design works with confidence. In addition, you should do a good job of strategy before purchasing to see if the scope of use of the product matches the space you use. For the 100,000-class clean workshop, we have considered water, electricity, gas, fire protection and environmental protection. In order to install air conditioning purification equipment, air ducts, air outlets, etc. The food industry clean room water supply and drainage system should have reliability acceptance from design, construction to production operation. The water supply and drainage of the clean workshop should meet the national standards, and facilities to prevent the spread of the medium should be set up on the ground where the equipment with corrosive medium discharged during the production process is located. The floors and walls are non-absorbent, impermeable, easy to clean and disinfect. The floor of the clean workshop should have a drainage slope of 1%--2%. Insect-proof and rat-proof grids or nets should be installed at the exit of the sewers and floor drains of the clean workshop. The importance of the decoration project of the 100,000-level clean workshop to product production 1. For the biological purification workshop project, the control objects are dust particles and microorganisms in the air. The requirements for the air cleanliness level, the unorganized species and concentration contained in the air, and the pressure difference are irrelevant for the biological purification workshops of different products or uses. In addition, this is the same as a clean room for integrated circuit production. The control object is mainly dust particles in the air. According to the feature size and integration degree of the integrated circuit, the requirements for air cleanliness level, micro-shock resistance, high-purity substances, etc. are different, and should be determined according to the product variety of a specific factory. 2. In order to ensure the air cleanliness required by the purification project of the purification workshop, each professional design involved in the purification project design of the purification workshop should take appropriate and reliable technical measures to reduce or prevent the generation of indoor dust, microorganisms, particulate matter microorganisms or possible damage. The cross-contaminated substances are brought to the artificial clean workshop decoration purification project. To effectively expel indoor particulate microorganisms, reduce or prevent their retention in clean room purification projects, when the cross-contamination of dust and brittle organisms or materials may compromise product rainfall or personal safety. In addition, safe and reliable technical measures should be taken to prevent cross-contamination. For example, it is necessary to strictly control the static pressure difference between the purification projects of different purification workshops, and reasonably divide the appropriate design of the purification air conditioning system and ventilation system according to the needs. The purification process design of clean workshop decoration is the synthesis of various professional design technologies, especially the process design, clean building design, air purification design and design technology for various special requirements. comprehensive design. The purification engineering design of the purification workshop should conform to the process (or use) process, reasonably select various types of pharma machinery and devices, try to achieve smooth and rapid flow of people and logistics, select the appropriate airflow type, rationally configure the purification air-conditioning system, and take technical measures for various special requirements. appropriate. 3. The formulation of clean pharmaceutical cleanroom decoration and purification projects must ensure safe production management and consider the needs of ecological and environmental protection. The small layout of the purification project in the clean workshop and the formulation of various infrastructures must meet the needs of fire and flame retardant, and be formulated according to the relevant benchmarks and standards of our country. Considering the horizontal and regional buckles, entrance bending and other properties in the cleaning project of the clean workshop, when completing the system development, facility hardware configuration and material selection of various technical infrastructures, special attention should be paid to the selection of systems and materials that meet the requirements according to the specifications. Preparation and materials. With the progress of scientific and technological progress, the refresh rate of industrial production is accelerated, and the public's demand for living standards is also increasing. The advantages of high technology, technology-intensive, and liquidity aggregation,In order to enhance the technical level, social and economic benefits after the clean workshop decoration and purification project is completed, when the clean workshop purification project is designed, the completed clean workshop purification project follows the development of science and technology.
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