Sterile Laboratory Air Tissue Form
Sterile Air Tissue Form
A sterile laboratory must maintain a certain temperature gradient and airflow. Under normal circumstances, the relative corridors and non-experimental areas in the sterile laboratory maintain negative pressure, and the airflow flows from the low-risk area to the high-risk area. The whole building must ensure positive pressure relative to the outside world to prevent harmful unpass...
Text label: laboratory, sterile laboratory, sterile laboratory equipment, sterile laboratory knowledge
Sterile Air Tissue Form
A sterile pharma machinery must maintain a certain temperature gradient and airflow. Under normal circumstances, the relative corridors and non-experimental areas in the sterile laboratory maintain a negative pressure, and the airflow flows from the low-risk area to the high-risk area. The entire building must ensure positive pressure relative to the outside world to prevent harmful unfiltered gases from infiltrating.
The air supply of the corridor should take into account the air supply of the sterile laboratory and the positive pressure requirements of the whole building. On the premise of a reasonable building layout, the positions of the air supply, return and exhaust should be fully considered. The matching of the air volume sent back and the exhaust air can establish a reasonable pressure gradient between the rooms to ensure orderly air circulation and prevent cross-contamination. In the design of the sterile laboratory, not only the flow direction of the air flow, but also the flow rate, the pressure difference between different cleanliness levels or different functional rooms, usually 5-10pa, and the pressure difference between adjacent different functional rooms in the biosafety sterile laboratory Usually 10-15pa, it is necessary to fully consider the flow of people and logistics routes, minimize indoor backflow and eddy currents, and avoid the spread of pollutants into the room, endangering the safety of personnel and the environment. Special attention should be paid to the influence of the detoxification cabinet on the indoor airflow organization. In the area near the detoxification cabinet and biological safety cabinet in the sterile laboratory, the occurrence of turbulence should be avoided as much as possible. Zhongjing Global Purification undertakes supporting services such as indoor sterile laboratory engineering, dust-free laboratory engineering design and construction, and purification pharmaceutical cleanroom equipment installation in various industries.
1. Pressure control of airflow
The pressure control of sterile laboratory mainly includes direct differential pressure control method and residual air volume control method.
1.1 Direct differential pressure control method
The direct differential pressure control method is to measure the differential pressure between the reference area and the reference area through differential pressure sensing. After comparing with the set differential pressure, the controller adjusts the air volume (or exhaust air volume) according to the deviation for control, so as to achieve the required Differential pressure, this pressure control method is feedback control, the response time of the system is long, and the control accuracy is low.
1.2 Residual air volume control method
A certain air volume difference (called residual air volume) between the air supply volume and the exhaust air volume of the sterile laboratory will inevitably lead to a certain pressure difference inside and outside the sterile laboratory. When the total indoor air supply is greater than the total indoor return air and exhaust air, the air is discharged through the residual pressure valve and the gap in the room, and a positive pressure is established with the adjacent area to prevent pollutants from entering the room. higher places.
When the total air supply volume of the room is less than the total amount of return air and exhaust air, the air enters the room from the outside through the adjacent room, and the room is under negative pressure. This type of negative pressure system is to ensure the safety of the environment and ensure that the untreated The pollutants will not flow outdoors, such as biosafety sterile laboratories, negative pressure animal rooms, etc. Advantages of residual air volume control method: accurate differential pressure control, small system fluctuation and rapid balance. The system belongs to feedforward control without external disturbance. The system has short response time and high control accuracy. Most clean rooms use this pressure control method.
For places that require pressure control and pressure stability (such as biosafety sterile laboratories), the residual air volume control method is often used as the basic control method, and pressure sensors and controllers are added to set the residual air volume. The air supply and exhaust volume are determined by the residual air volume that generates the pressure difference, and the residual air volume is detected at the same time. When the residual air volume deviates from the set value to a certain extent, the system will automatically alarm. At this time, the measuring device or the equipment that may cause air leakage ( Such as air duct system, building envelope) for processing. The combination of residual air volume control and pressure control can realize the dynamic control of the system and ensure the accuracy of the pressure difference in the pressure system.
2. Exhaust equipment
The number and exhaust air volume of sterile laboratory exhaust equipment are important factors to consider in the design of sterile laboratory air conditioning systems. Common laboratory exhaust equipment includes detoxification cabinets, universal exhaust hoods, atomic absorption hoods, Desktop fume hoods, biological safety cabinets, exhausted reagent cabinets, glove boxes, etc.
3. Factors of cooling and heating load
The design of the sterile laboratory air-conditioning system must fully consider the potential heat and cold sources of the pharma machinery, so as to calculate the scientific and accurate cooling capacity and use the inverter air conditioner to achieve the purpose of energy saving. Common cold and heat loads in sterile laboratories include sensible heat of personnel, sensible heat of animals, laboratory equipment, computers, lights, cooling rooms, and heating rooms.
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