Granule clean workshop
Granule clean pharmaceutical cleanroom
Granulation is an important link in the production of solid preparations. It is divided into two categories: wet granulation and dry granulation. The shape and size of granules produced by different granulation technologies are different. , material properties, etc.; wet granulation is the addition of wetting agent or liquid viscosity to the material...
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Granule clean workshop
Granulation is an important link in the production of solid preparations. It is divided into two categories: wet granulation and dry granulation. The shape and size of granules produced by different granulation technologies are different. , material properties, etc.; wet granulation is a method of adding wetting agents or liquid binders to granulate materials to obtain uniform particle size, good compressibility, fluidity, and strong wear resistance; extrusion granulation It is a traditional granulation method, which can control the pore size adjustment of the screen according to the size and softness of the particles, and add different adhesives for granulation. Continuous production requires frequent replacement of the screen; making soft material is a key step in extrusion granulation. hard.
Making wet granules is to forcibly extrude the obtained soft material through a screen with a certain size of aperture to make wet granules. The wet granules should be uniform in size, less fine powder and no long strips. The commonly used equipment in production is swing type In the granulator, the granules should be dried, preferably at 50-60 °C. During the drying process, some granules may stick together, so give proper granulation, and finally obtain uniform granules with a certain particle size. The material is put into the high-speed stirring and granulating container, and the binder is added after stirring and mixing. The commonly used high-speed stirring granulator is divided into two types: horizontal type and vertical type. The structure is mainly composed of mixing tank, stirring blade, cutting knife, etc. The main factors affecting particle size and compactness are the type of binder and the amount added. According to the mixing method, stirring speed, particle size of raw material powder, etc., the prepared wet granules need to be dried and granulated. High-speed stirring and granulating, mixing, kneading and granulating in one container, the operation is simple and fast; granules with different tightness can be prepared; the preparation process is airtight to avoid pollution and dust flying; the growth process of granules is not easy to control. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for clean workshops and clean workshops.
Dry granulation is to mix the materials evenly, press them into blocks, flakes, etc. with suitable equipment, and then crush them into particles of suitable size. No wetting agent or liquid binder is required in the granulation process. It also does not need to be dried, and is often used for granulation of heat-sensitive materials and easily decomposed materials in contact with water. 20-25mm in diameter, and then crushed into particles of the required size. This method is simple to operate, but the pressure is high, the die and other mechanical equipment are easily damaged, and the raw materials are also lost to a certain extent; the rolling method is to mix the drug with the material powder. After homogenization, it is pressed through the gap between two rolling cylinders with the same rotation speed to form a sheet of required hardness, and then broken into particles of a certain size.
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