Air conditioning system settings in purification workshop
Air conditioning system settings in purification workshop
The air conditioning system of the purification pharmaceutical cleanroom should be set according to the requirements of the corresponding level. In the workshop facilities, in order to prevent pollution and cross-contamination, the doors and windows of the workshop should be airtight, and there should be good ventilation, dust removal, noise reduction and other facilities; Therefore, the ventilation device in the workshop is a must...
Text label: purification workshop system, purification workshop setup and installation, air conditioning system setup
Purification workshop air conditioning system settings
The air conditioning system of the purification workshop should be set according to the requirements of the corresponding level. In the workshop facilities, in order to prevent pollution and cross-contamination, the doors and windows of the workshop should be airtight, and there should be good ventilation, dust removal, noise reduction and other facilities; Therefore, the ventilation device in the workshop is essential. The A-level area is used as a high-risk operation area, such as the filling area, the area where the rubber stopper barrel and the open packaging container in direct contact with the sterile preparation are placed, and the area where the aseptic preparation or linking operation is performed shall adopt a one-way flow device. Maintain the environmental status of the A-level area. In the design of the A-level unidirectional flow area with the air cleanliness B as the background, the unitized unidirectional flow device is sometimes assembled and combined, and the built-in or external fan is used for full-cycle operation; when the unidirectional flow device has a larger area When it is large, or when the circulating air of the one-way flow device cannot be fully exchanged with the air in the B-level area, the A-level area will cause the heat to accumulate during the continuous circulation of the air, causing the temperature in the A-level area to be higher than room temperature. phenomenon, even exceeding the ambient temperature required by the process production.
The temperature in the area of u200bu200bair cleanliness class A should not exceed the indoor design temperature by 2°C, and the maximum should not be higher than 24°C. If it exceeds, it is necessary to introduce a purifying air conditioning system into a one-way flow device or a circulating air system Measures such as supplying air or adding dry cooling coils; when the fan filter unit FFU is used in combination with dry cooling coils, the cooling coils need to be installed on the return air passage of the FFU, and the inlet temperature of the refrigerant should not be Below the air dew point temperature, the passing wind speed should be less than 2m/s. Although the dry cooler does not have condensed water precipitation during normal operation, a drip tray should still be installed; The B-level area maintains a reasonable airflow organization form of upper and lower return, and the position of the air return port of the one-way flow device should be arranged in the lower part of the room; when the air return port of the one-way flow device is in the upper part of the box or the upper part of the process equipment, The method of setting the return air outlet at the lower part of the room through the air duct should be preferred; the indoor environment with one-way flow device, such as the aseptic work clothes finishing table in the laundry room, sampling room, quality control pharma machinery, etc. The flow direction area can not be restricted by the lower return air; when using the side wall return air or the ground grille return air, you must pay attention to the design of the return air grille, so as to facilitate the effective cleaning of the grille and the bottom air duct Work. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for purification workshops and purification plants.
In the area of u200bu200bair cleanliness level A, especially in the adjacent edge area of u200bu200bthe B level area, the air flow pattern of the unidirectional flow will not be disturbed or damaged. It is very effective to set a transparent and easy-to-operate enclosure on the outer edge of the unidirectional flow device , Usually transparent rigid partition or PVC film can be used, and the height should be lower than the operating surface. In order to ensure the air cleanliness level of the working surface, the height of the enclosure from the ground should not be greater than 0.5m; The specification requires that it be kept at 0.45m/s, and then in the non-production state, the pollution source in the A-level area can be evacuated, which can reduce the flow rate, maintain low-frequency operation, save energy and reduce consumption. It is recommended that the fan in the unidirectional flow unit adopts frequency conversion speed regulation ; The specific value of low frequency operation should be verified according to the situation of each unidirectional flow unit to confirm that it can meet the specified level requirements.
The total pressure of the fan in the purification air conditioning system is much higher than that of the general air conditioner, so there are higher requirements for the strength and air tightness of the air handling unit. When the static pressure in the air conditioning box is 1000Pa, the air leakage rate shall not be greater than 1% , The overall structure of the equipment must have sufficient strength, and there must be no deformation during transportation, installation, and operation; when calculating the total air supply volume of the purification air conditioning system, the air leakage volume of the air conditioning equipment and the air duct system should be included, which is about 5%-10 %, this air leakage also includes the increase of fresh air volume. In accordance with the requirements of purification workshop operation management and energy saving, the air-conditioning purification system should adopt the fan automatic speed control device; under any operating state, the clean area should be able to ensure that through proper air supply. The positive pressure and aseptic production clean area air purification system for surrounding low-level areas should be kept in continuous operation to maintain the corresponding cleanliness level. Therefore, when the supply of air to the clean area cannot be guaranteed due to the power failure or the failure of the purification air conditioning fan, It will bring risks to product quality or cause economic losses; usually after a power outage of 3min-4min, the number of particles in the B-level area will exceed the limit, so it is proposed that the air conditioning system serving the sterile area should be powered by secondary load.
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