Maintenance of refrigeration equipment in sterile room workshop

The maintenance of refrigeration equipment is divided into fault maintenance and regular maintenance; the container of the refrigeration device, in the ammonia refrigeration system, includes a high-pressure liquid storage tank, an intercooler, an oil collector, a drain tank, a low-pressure circulating liquid storage tank, etc. , the heat exchanger includes condenser, evaporator, subcooler and cooling...
Text label: sterile workshop refrigeration equipment, sterile room equipment, sterile pharmaceutical cleanroom design and decoration

Overhaul of refrigeration equipment in sterile room workshop


The maintenance of refrigeration equipment is divided into fault maintenance and regular maintenance; the container of the refrigeration device, in the ammonia refrigeration system, includes a high-pressure liquid storage tank, an intercooler, an oil collector, a drain tank, a low-pressure circulating liquid storage tank, etc. , Heat exchangers include condensers, evaporators, recoolers and cooling pipes, etc. There are many types of containers and heat exchangers, and their functions are different. The causes of damage and the methods of repair are similar. The reasons for the damage of the container and the heat exchanger: the working surface is polluted, and the working surface of the container and the heat exchanger is polluted, which will reduce the effective area and the container, reduce the heat exchange efficiency, and increase the fluid resistance; there is scale on the outer surface of the heat exchanger and The phenomenon of crystallization and precipitation occurs in the brine solution; the anti-rust paint of equipment and pipelines falls off, and rust occurs on the outer surface; mechanical impurities, lubricating oil, etc. enter the equipment, especially low-pressure equipment, the viscosity of the oil increases, plus The mixing of impurities can easily cause blockage of the pipeline.


The connection of each part of the refrigeration equipment is in a sealed state. If the sealing ability is lost, it will cause leakage and affect production; the pre-tightening force of the bolts of the flange does not meet the requirements, and the bolt connection is too loose, so the pre-tightening force cannot be guaranteed , Over-tightening may cause plastic deformation of the bolt or crush the packing. Therefore, due to the influence of vibration and high temperature, the pre-tightening force can also be gradually reduced. In addition, the flange bolts are rusted and other reasons to cause fatigue deformation and reduce the pre-tightening force; Weld cracks caused by fatigue and cold brittleness of metal materials; fillers at flanges or valve stems are corroded, worn or aged. Refrigeration equipment is corroded by the medium and rubbed by other objects, and it will decrease continuously. When the thickness is close to the minimum allowable value of strength calculation, the equipment should be used under reduced pressure or scrapped; cracks or needle-shaped holes often appear near welds, pipes Elbow, finned tube spot welding, and places where the antirust paint of equipment pipeline is severely corroded after peeling off, in addition, there are leaks in the seamless tube itself in very rare cases; when spot welding of finned tubes, care should be taken not to rub the tube wall. The melting is too heavy, resulting in thinning of the tube wall, and the corrosion of the metal causes pinholes to appear there. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for sterile rooms and sterile workshops.














Preparations should be made in advance when repairing vessels, heat exchangers and pipes. Masks, rubber gloves, ventilators, etc. should be prepared for the ammonia system; This work must be done carefully, and each valve that is closed must be clearly marked to prevent the operator from opening the wrong valve when the equipment pipeline is repaired; the repaired container or pipeline should be evacuated. If the high-pressure liquid equipment such as For the maintenance of the high-pressure liquid storage tank, the liquid should be pumped out first, and the relevant valve connected with the condenser should be closed first, and the connection with the condenser should be cut off. Supply to each room of the cold storage; after the liquid is processed, the pressure in the barrel can be pumped directly to the pressure of the low-pressure system with the liquid supply pipe to observe the increase of the pressure in the barrel. Eliminate; if the pressure rise in the barrel is small, it can be considered that the valve is not leaking, and the remaining gas in the barrel can be put into the water through the oil drain pipeline and the relevant valve pipeline of the oil collector, and then repair the defect. Blowing is generally carried out with an air compressor, and its working pressure is 0.59MPa, and it is required to blow clean when blowing.
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In recent years, mushroom cultivation has evolved from traditional methods in outdoor environments to sophisticated processes within highly controlled clean rooms. This shift has been driven by the need for higher yields, better quality, and reducing contamination risks. As mushroom farming continues to grow in popularity, the importance of understanding the challenges and techniques associated with clean room cultivation cannot be overstated. Whether you are a seasoned grower or just starting, this article will delve into the intricacies of this method to help you succeed.

Understanding the Concept of Clean Room Cultivation

Clean room cultivation for mushrooms involves growing mushrooms in a highly controlled, contaminant-free environment. The primary idea behind using clean rooms is to minimize the chances of contamination from mold, bacteria, or pests, which can affect the quality and quantity of the mushrooms produced. These environments are maintained with strict protocols that include air filtration, surface sterilization, and regulated entry for personnel.

The implementation of clean rooms in mushroom farming offers numerous advantages. The most notable is the ability to produce mushrooms year-round, regardless of outdoor weather conditions. This control over the growing environment allows for the optimization of factors such as temperature, humidity, and CO2 levels, which are crucial for the optimal growth of mushrooms. Moreover, clean rooms can significantly accelerate the cultivation cycle, leading to multiple harvests within a shorter time span.

Despite these advantages, the initial setup of a clean room requires a significant investment. The costs associated with building and maintaining a contamination-free environment can be substantial. This includes purchasing HEPA filters, UV sterilization pharma machinery, and ensuring the room’s air pressure remains positive to prevent outside air from entering. Nevertheless, for those serious about mushroom cultivation, the long-term benefits often outweigh the initial investment.

Key Challenges in Clean Room Mushroom Cultivation

While clean rooms offer a controlled cultivation environment, they are not without their own set of challenges. One of the primary issues growers face is the control of contaminants. Even in the most meticulously maintained clean room, the risk of contamination cannot be entirely eliminated. Fungi are notorious for their ability to spread rapidly, and any lapse in protocol can lead to significant crop losses.

Another significant challenge is maintaining an optimal microclimate. Factors such as humidity, temperature, and light must be carefully regulated to mimic the natural conditions that mushrooms thrive in. This requires sophisticated environmental control systems. Even slight deviations from the ideal conditions can lead to poor growth or even failure of the crop.

Labor costs also tend to be higher in clean room cultivation. The need for specialized training and stringent protocols means that workers must be highly skilled and conscientious. Regular monitoring and maintenance of the clean room further add to labor expenses.

Finally, the energy consumption required to maintain a clean room is another challenge. Air filtration, temperature regulation, and humidity control are energy-intensive processes. This not only has financial implications but also raises concerns about the environmental impact.

Essential Techniques for Successful Cultivation

To overcome the challenges associated with clean room cultivation, growers employ a variety of techniques. The first crucial step is ensuring that the room itself is properly designed and equipped. This includes using high-efficiency particulate air (HEPA) filters to remove airborne contaminants and maintaining positive air pressure to keep outside particles from entering the room.

Sterilization is another key component. All surfaces and pharma machinery must be regularly cleaned and sterilized using chemicals like isopropyl alcohol or hydrogen peroxide. Additionally, UV lights can be used to kill microorganisms in the air and on surfaces.

Environmental control systems play a crucial role in maintaining the conditions necessary for mushroom growth. Advanced climate control systems allow growers to precisely regulate temperature, humidity, and CO2 levels. Many systems are now automated, enabling continuous monitoring and adjustments to ensure optimal growing conditions.

Another important technique is implementing a strict sanitation protocol for personnel. This includes using protective clothing, such as gloves and masks, and ensuring that hands and footwear are sterilized before entering the clean room. Limiting the number of people who enter the room can also help reduce the risk of contamination.

Using high-quality spawn and substrates is essential for successful clean room cultivation. The spawn must be free of contaminants, and the substrate must be properly sterilized before inoculation. Many growers opt for commercial substrates and spawn that have been tested for purity, reducing the risk of introducing contaminants into the clean room.

The Role of Technology in Enhancing Clean Room Cultivation

Technology has revolutionized the way mushrooms are cultivated in clean rooms. One of the most significant advancements is the automation of environmental control systems. These systems use sensors and computer algorithms to constantly monitor and adjust conditions within the clean room, ensuring that they remain optimal for mushroom growth. This reduces the need for manual adjustments and allows for more consistent results.

Another technological advancement is the use of remote monitoring systems. These systems enable growers to check the status of their clean room and make necessary adjustments from anywhere in the world. This is particularly beneficial for those who manage multiple clean rooms or who cannot be on-site at all times.

Data analytics also plays a crucial role. By collecting and analyzing data on various environmental parameters, growers can identify trends and make informed decisions to optimize their cultivation processes. This can lead to higher yields and better-quality mushrooms.

Advanced sterilization technologies, such as ozone generators and antimicrobial surfaces, are also being incorporated into clean rooms. These technologies provide additional layers of protection against contaminants, further reducing the risk of crop loss.

Furthermore, innovative techniques in spawn production and substrate preparation are being developed to enhance the efficiency and effectiveness of clean room cultivation. These include genetic improvements in mushroom strains and the use of novel substrate materials that promote faster and more robust growth.

The Future of Mushroom Clean Room Cultivation

The future of clean room mushroom cultivation looks promising, with continuous advancements in technology and growing interest from both small-scale and commercial growers. Integration of artificial intelligence (AI) and machine learning is one of the most exciting developments on the horizon. These technologies have the potential to further enhance the precision and efficiency of environmental control systems, leading to even better yields and quality.

Another trend is the increasing focus on sustainability. As concerns about energy consumption and environmental impact grow, researchers and industry professionals are exploring ways to make clean room cultivation more eco-friendly. This includes developing energy-efficient pharma machinery and exploring renewable energy sources to power clean rooms.

Collaboration between academic institutions, industry, and government agencies is also expected to drive innovation in clean room cultivation. Research initiatives aimed at understanding the best practices for mushroom cultivation in controlled environments are likely to yield valuable insights that can be applied in real-world settings.

Moreover, consumer demand for high-quality, contaminant-free mushrooms is on the rise. This demand is expected to drive further investment in clean room cultivation, leading to the development of new products and growing techniques that cater to the needs of both consumers and growers.

In summary, while the challenges of clean room mushroom cultivation are significant, the benefits and possibilities it offers make it an appealing option for those committed to producing high-quality mushrooms. Advances in technology and a focus on sustainability are likely to shape the future of this cultivation method, paving the way for even greater success in the years to come.

In conclusion, mushroom clean room cultivation presents a unique set of challenges and techniques that require careful planning, investment, and ongoing management. From understanding the concept and addressing key challenges to implementing essential techniques and leveraging technology, growers have numerous tools at their disposal to optimize their operations. As the industry continues to evolve, the future holds exciting possibilities for those who embrace the principles of clean room cultivation. By staying informed and adaptable, mushroom growers can look forward to enjoying the many benefits that this innovative approach has to offer.

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