Small-volume oral liquid GMP workshop layout
Small-volume oral liquid GMP workshop layout
Small-capacity oral liquid linkage line consists of three stand-alone machines: vertical ultrasonic bottle washing machine, tunnel type sterilization dryer or far-infrared hot air circulation tunnel type sterilization dryer, and oral liquid filling and rolling integrated machine. Three working areas for drying and sterilization, filling and capping; oral liquid filling and rolling...
Text label: Oral liquid GMP workshop layout, small volume oral liquid workshop
Plant layout of small volume oral liquid GMP pharmaceutical cleanroom
Small-capacity oral liquid linkage line consists of three stand-alone machines: vertical ultrasonic bottle washing machine, tunnel type sterilization dryer or far-infrared hot air circulation tunnel type sterilization dryer, and oral liquid filling and rolling integrated machine. Three working areas: drying, sterilization, filling and capping; the oral liquid filling and rolling integrated machine adopts a large dial wheel for bottle feeding, reciprocating rotation tracking filling and single- or three-knife capping, and automatically completes bottle feeding, bottle feeding and filling. Filling, burying, capping and other processes, the filling form can be filled with glass pump, metal pump, ceramic pump or peristaltic pump according to user requirements; bottle conveying device is used for bottle storage and conveying bottles, powered by AC motor, The bottle feeding speed is controlled by the frequency converter, which can be steplessly adjusted. The packaging bottles are continuously sent to the auger under the driving of the conveyor belt, and the bottle feeding can be carried out without stopping the machine.
Filling needle tracking adopts the reciprocating tracking filling system on the rotating large dial, which simplifies the transmission structure of the mechanism, the transmission and positioning are accurate, the bottle travels smoothly, and the noise is low, which greatly reduces the failure rate and the use cost, and at the same time ensures the bottle during the transmission process. No pollution particles are produced in the middle of the bottle, which prevents the bottle from being damaged and broken during the transmission process; the cap-arranging bucket is mainly made of the principle of electromagnetic resonance. The high and low position, adjusting the vibration voltage can adjust the capping speed. The caps arranged by the capping bucket are arranged in the channel. When the canned bottle passes through the cap-wearing part under the conveying of the intermediate conveyor belt, the bottle is hung with the cap and slides down through the gland plate. out, so that the cap is put on correctly, so that every time a bottle is passed, a cap is put on; the capping part is mainly composed of the bottle holder part, the gear sleeve part, the knife arm part, the capping cam, the capping cam and other main parts. The method is divided into three-knife capping method, central single-knife capping method or side-mounted single-knife capping method, which has the advantages of simple structure, stable operation and reliable operation. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for GMP workshops and GMP workshops.
After the bottle with the cap in the GMP workshop enters the capping group, with the movement of the machine, the gear sleeve part moves down along the track of the capping cam. When the rotating press head touches the bottle, the bottle holder will continue to move downward. Until it touches the conical surface of the gear shaft inside the bottle holder part, the two conical surfaces fit together to generate friction, and then the rotating gear shaft rotates synchronously with the bottle holder sleeve. The process layout requirements of small-volume oral liquid: the washing bottle is at grade D, the filling and sealing area is at grade C; the filling can be considered at grade A in the environment of grade C or grade B; the pressure of purified water shall not be less than 1.5kg; It should not be less than the specified capacity; the air pressure at the bottle outlet > the air pressure at the bottle inlet; when the sterilization temperature is 350 ℃, it should not be less than 5 minutes.
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