Production process and layout of syrup in purification workshop
Production process and layout of syrup in purification workshop
Syrups in purification workshops are generally prepared by dissolution method or mixing method. For the dissolution method, take an appropriate amount of purified water, boil, add sucrose, heat and stir to dissolve, continue to heat to 100°C, add stirring to dissolve at a suitable temperature, and filter while hot , add an appropriate amount of new boiling water from the filter...
Text label: syrup production purification workshop, clean workshop process flow, layout
Production process and layout of syrup agent in purification workshop
Syrups in purification workshops are generally prepared by dissolution method or mixing method. For the dissolution method, take an appropriate amount of purified water, boil, add sucrose, heat and stir to dissolve, continue to heat to 100°C, add stirring to dissolve at a suitable temperature, and filter while hot , add an appropriate amount of freshly boiled purified water from the filter to make it into the prescribed amount and stir well; if it is a water-soluble solid, a small amount of freshly boiled purified water can be used to make a concentrated solution, which has a low solubility in water. If it is a mixable liquid or liquid preparation, it can be directly added to the simple syrup and stirred well, and if necessary, it can be obtained by filtering; The production process can be simplified to the washing and drying of the container, the sugar-dissolving filtration, the batching, the potting and the packaging process.
Container washing and drying equipment: This process includes the washing and drying of glass bottles and rubber stoppers, and the processing of aluminum-plastic caps, etc. The commonly used equipment is basically the same as the related equipment for oral liquids. Sugar-dissolving filter equipment, dissolve sucrose with purified water, sterilize by boiling, filter and clarify, and send it to the preparation process after cooling. Syrup filling process: This process is an open station, which requires isolation from outsiders to control the cleanliness of the environment and ensure the quality of the product. Sealed vacuum filling machine; according to the different quantitative filling methods, there are vacuum type, pressurized type and plunger type, etc., and the filling station has linear type and turntable type; linear liquid filling machine will clean and dry After the container is sorted, it is placed in the bottle unscrambler and rotates with it. Under the action of the bottle dial and the bottle calibrator, it regularly enters the bottle delivery track. The bottle entering the track moves linearly with the chain plate and enters the bottle. Filling station; the container with the solution enters the capping machine, and after capping and capping, the entire filling process is completed. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for purification workshops and clean workshops.
The syrup production workshop should be reasonably arranged according to the process requirements, personnel and logistics should be separated, and the upper and lower processes of the production pharmaceutical cleanroom should be connected easily; the walls, floors and ceilings in the purification workshop should be smooth and clean, without cracks, shedding substances and shells, and it is not easy to Dust accumulation, no mold growth; water and electricity process pipelines should be installed concealed; the air cleanliness level of the preparation, filtration and potting of non-terminally sterilized syrups is at least C, and the air cleanliness of the exposure process of terminally sterilized syrups is the lowest. Class D; the cleanliness level of the exposure process of the final treatment of the packaging materials should be the same as the production environment of the liquid medicine; the production equipment is adapted to the production requirements, which is convenient for production operation, maintenance and maintenance; the internal working conditions of the sterilization equipment are detected by instruments, and the detection instruments Regular calibration and complete records; water storage tanks, water pipelines, pipe fittings and valves, etc. should be made of corrosion-resistant materials; the storage conditions of raw materials, auxiliary materials and guaranteed materials should not be damp, deteriorated, polluted or prone to errors; set up visiting corridors and Corresponding safety doors should be considered when cleaning corridors; air-conditioning room, power, and water production are arranged around the clean area and close to the clean area, so that air-conditioning air ducts and various pipelines can be transported in the shortest distance, reducing energy consumption and investment; The measuring room should be close to the preparation and filtration room, so that the materials can be transported in the shortest distance and reduce pollution.
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