GMP workshop preparation drying

GMP pharmaceutical cleanroom preparation drying

GMP workshop drying is the operation of using heat energy to vaporize the moisture in the material, and using airflow or vacuum to take away the vaporized moisture to obtain dry products. Most of the moisture removed by drying is water, and air is generally used to remove moisture. Separate airflow; drying is an important unit operation in the production of preparations, such as solid...

Text label: GMP pharmaceutical cleanroom design, GMP pharmaceutical cleanroom purification engineering, GMP workshop preparation drying

GMP workshop preparation drying

GMP workshop drying is the operation of using heat energy to vaporize the moisture in the material, and using airflow or vacuum to take away the vaporized moisture to obtain dry products. Most of the moisture removed by drying is water, and air is generally used to remove moisture. Drying is an important unit operation in the production of preparations, such as solid raw materials, wet granulation, auxiliary materials, etc. all need to be dried; the purpose of drying is to control the moisture content of materials, which is convenient for material processing, transportation, storage and use, Guarantee quality and improve stability; but if the material is too dry, it is easy to generate static electricity, or it is easy to produce cracks when pressing, which will cause disadvantages to the production process; in the process of convection drying, the hot air is in contact with the wet material. The surface is then transferred from the surface to the interior of the material, which is a heat transfer process; after the wet material is heated, the surface moisture first vaporizes, and the internal moisture diffuses to the surface of the material in a liquid or gaseous state, and continuously vaporizes into the air, which is a mass transfer process. process.

In the constant-speed drying stage, the moisture content in the material is high, the moisture on the surface of the material is vaporized and diffused into the air, and the moisture inside the material is replenished to the surface in time to maintain a fully wetted surface state. This process is completely consistent with pure The vaporization of water is the same, and the drying rate depends on the vaporization rate of water on the surface, which is mainly affected by the external conditions of the material. The acceleration methods at this stage are: increase the air temperature or reduce the humidity in the air to improve the driving force of heat transfer and mass transfer; improve the contact between the material and the air, increase the flow rate of the air to make the air film on the surface of the material thinner to reduce the transfer rate. Resistance to heat and mass transfer. Due to the different properties, drying degree and production capacity of the materials to be dried, the drying methods and equipment used are also different. The chamber dryer mainly uses hot air to pass through the surface of the wet material to achieve the purpose of drying. Multiple brackets are set in the drying chamber, and a material tray is placed on the bracket. After preheating, the air enters the drying chamber and passes through the surface of the material in a horizontal direction. Drying; in order to make the drying uniform, the material layer in the drying tray should not be too thick. If necessary, open holes on the drying tray, or use a mesh drying tray to allow air to pass through the material layer. Chamber dryers mostly use exhaust gas circulation method and intermediate heating method. The equipment is simple and adaptable. It is widely used in batch drying of materials with low production volume in the production of preparations, but it has disadvantages such as high labor intensity and high heat consumption. ; The particles of the material to be dried may contain soluble components. Since the soluble components can migrate between the particles, resulting in differences in the content between the particles and affecting the uniformity, the particles in the tray should be frequently turned during the drying process. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for GMP workshops and clean workshops.

Infrared dryer is a drying method that uses infrared rays emitted by infrared radiation elements to directly irradiate and heat materials. Infrared is an electromagnetic wave between visible light and microwave, and its wavelength is in a wide range of 0.72-1000μm. The wavelength in the 0.72-5.6μm region is called near-infrared, and the wavelength in the 5.6-1000μm region is called far-infrared; when infrared drying, because the material surface and internal material molecules absorb infrared at the same time, the heating is uniform, drying is fast, and the quality is good. The disadvantage is that Power consumption is large. Spray drying is a method of spraying the solution into the drying chamber for drying. Due to the large evaporation area and very short drying time, the temperature of the droplets during the drying process is roughly equal to the wet bulb temperature of the air, generally around 50 °C. For heat-sensitive materials It is very suitable for aseptic operation; dry products are mostly crisp hollow particles with good solubility, and the feed liquid and hot air fed into the spray dryer can be filtered through a sterilizing high-efficiency filter to obtain sterile dry products.

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