Design and construction of suppository production purification workshop

Design and construction of suppository production purification pharmaceutical cleanroom

The suppository production line in the purification workshop is used to prepare suppositories, and can also be processed into small-dose oral liquids and children's food; the basic working process of the suppository filling and sealing unit is tape making, filling, condensation, sealing, printing batch numbers, and aligning the top. , cut, etc., rolls of plastic sheets or aluminum...

Text label: Suppository production purification pharmaceutical cleanroom, clean workshop design and construction

Design and construction of suppository production purification workshop

The suppository production line in the purification workshop is used to prepare suppositories, and can also be processed into small-dose oral liquids and children's food; the basic working process of the suppository filling and sealing unit is tape making, filling, condensation, sealing, printing batch numbers, and aligning the top. , shearing, etc., the rolled plastic sheet or aluminum foil sheet is subjected to positive pressure blow molding by a suppository belt making machine or welded by a welding mold, and then enters the filling station, and the uniformly stirred liquid is measured by high precision. After the device is automatically poured into the empty shell, it is cut into strips and then enters the cooling station. Suppositories are made by batch numbering, aligning the top, and counting and shearing. The suppository filling and sealing unit in the purification workshop is controlled by frequency conversion. When adjusting the speed in automatic operation, you only need to adjust the frequency of the belt-making motor, and the motors of the freezer and sealing machine will automatically match it. Hot molds, welding molds, and knurling molds, of which preheating molds and welding molds need to be heated, and the mold material requires wear resistance, good thermal conductivity, and small thermal deformation.

The temperature requirements of the belt making machine mold and the sealing machine mold in the suppository filling and sealing unit should be able to be set, and the displayed temperature error should not be greater than ±2℃. Minor adjustments may be made, and its temperature directly affects the heat sealability of welding, the fullness of the bubble shape, the firmness of welding and whether it is easy to tear; the starting pressure must meet the specified requirements, when the pressure is low, the sealing is not good, and when the pressure is high, it is not easy to tear ;The filling amount can be adjusted arbitrarily within the specified range of each piece according to the needs, the adjustment is carried out on the man-machine interface, and the current filling amount and current density are written in the corresponding position of the perfusion interface, and the equipment is automatically adjusted to the set filling amount through the servo motor. Each channel can be achieved by fine-tuning the perfusion accuracy. The ordinary suppository filling and sealing machine in the purification pharmaceutical cleanroom has the characteristics: wide adaptability, can be filled with difficult gelatin substrates and preparations; large capacity of the liquid storage tank, equipped with constant temperature and stirring devices. The continuous suppository unit is filled with a servo motor system, which is accurate and convenient to adjust the filling volume, with a menu storage function, and easy to change specifications; the waste products are not filled, and automatically punched and automatically rejected at the end of the machine; shutdown cooling protection, continuous tape out , Low rejection rate; continuous tape production, continuous sealing, and the number of shearing particles can be set arbitrarily. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for suppository production purification workshops and clean workshops.

The ordinary suppository filling and sealing unit in the purification workshop should check whether the water pipe and air pipe leak before each shift, and it can be turned on after normal; Wipe and clean the outer surface and interior of the machine with a clean hot towel every day; the leaking sealing components should be replaced irregularly, especially the sealing ring of the mandrel. Regularly add pure water, check every day whether the speed regulating joint is loose or not, and whether the air pipe joint is leaking; regularly check whether the indicator lights of the magnetic switch and electromagnetic reversing valve are on and working normally; if the equipment is not used for more than 15 days, the equipment should be started once to carry out 4H air-carried operation to ensure normal production at any time. If there is a situation that cannot be handled, the manufacturer should be notified in time to send professional technicians to deal with it.

To clean the filling barrel, turn off the stirring motor and plunger pump, open the discharge port of the feeding valve, rinse with 80-90 ℃ hot water for three times, and wipe it with a hot and humid clean mask cloth; Remove the plugs of the feeding pipes at both ends of the perfusion head, unscrew the two fixed handle buttons of the perfusion head, and loosen the 6 core shaft spare caps. After removing the perfusion head, pull out the perfusion plug, and push out the perfusion valve in turn; the plunger To clean the pump, after removing the plunger pump, remove the upper and lower nylon plugs, take out the plunger and soak it in hot water for 5 minutes, brush with a fine-bristle brush until there is no residual material in the plunger and various parts, and then clean the mask with heat and humidity. The cloth is cleaned for use; for the cleaning of the feeding pipe, connect the feeding valve to the feeding pipe of the plunger pump, the feeding pipe of the plunger pump to the injection head, and the return pipe from the filling head to the filling bucket, and put in hot water. Soak for 10 minutes, then pour hot water into the tube and rinse it back and forth three times until there is no residue on the inner wall of the tube, hang the feeding tube to dry until there is no water in the tube; clean and clean the feeding track, use hot air to fill the feeding track Clean up and wipe it with a hot towel, use a hot air blower to clean the refrigerated feed trough, and wipe it with a hot towel, and use tweezers to hold the hot clean mask cloth for the support plate of the sealing part.

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