Dehumidification measures in tablet cleaning workshop
Dehumidification measures in tablet cleaning workshop
Dehumidification requirements for tablet clean room:
During the tableting process, too fine powder or itself contains hygroscopic items, they are particularly easy to absorb moisture and become sticky, which affects the quality of the product. Therefore, some tablet powder production and capsule production require very low relative humidity, but...
Text label: Tablet clean pharmaceutical cleanroom, Dehumidification measures in tablet workshop
Dehumidification measures in tablet clean room
Dehumidification requirements for tablet clean room:
During the tableting process, too fine powder or itself contains hygroscopic items, they are particularly easy to absorb moisture and become sticky, which affects the quality of the product. Therefore, some tablet powder production and capsule production require very low relative humidity, but after the air is too dry, the powder particles are too dry, and the items containing crystal water lose too much water, and cracks appear during the tableting process. affect product quality. Therefore, the production of tablet powder not only requires low humidity, but also sometimes requires that the humidity range should not be too large.
When the relative air humidity is required to be lower than 50% or even 45%, it is difficult to achieve the purpose of freezing and dehumidification. Among many dehumidification measures, lithium chloride rotary dehumidification is obviously more suitable.
Lithium chloride rotary dehumidifier is mainly composed of three parts: dehumidification system, regeneration system and control system. The structure of the rotary dehumidifier as the main dehumidification system is shown in the figure.
Lithium chloride dehumidifier works as follows:
When the process air that needs to be dehumidified enters the moisture absorption zone 7 of the runner through the filter 11 from the inlet 12, because the runner is processed into dense honeycomb-shaped channels with hygroscopic paper, the moisture exchange area is very large, and the volume per cubic meter is about There is a hygroscopic area of u200bu200b3000m2, and the moist air can fully contact the absorbent on the absorbent paper. Most of the water vapor contained is absorbed by the lithium chloride crystals embedded in the absorbent paper, retained on the absorbent paper, and releases the latent heat of vaporization. Then, the process air passing through the hygroscopic zone of the rotor becomes dry air with reduced humidity and increased temperature, and is discharged from the outlet 5 at the other end.
The air used for regeneration passes through the inlet 3, passes through the regeneration air filter 2 and the regeneration air heater 8, is heated to 120°C, and is sent into the regeneration area of u200bu200bthe runner box in the opposite direction, from the honeycomb of the runner paper core. The temperature of the hygroscopic paper core increases, and the moisture contained in it is vaporized and brought out of the box by the hot air and discharged to the outside from the outlet 13.
Rotary dehumidifiers are available in various forms such as vertical, horizontal, assembled, heat recovery and activated carbon adsorption.
Among them, the energy recovery type is a runner made of aluminum foil, non-metallic film, special paper, etc. treated with a special process. In winter, the temperature and humidity of the exhaust air are higher than those of the fresh air, which will increase the temperature of the rotating core and increase the moisture content. Summer is the opposite. Zhongjing Global Purification can provide supporting services such as consultation, planning, design, construction, installation and transformation of clean workshops and GMP workshops.
Rotary Dehumidifier System
Dehumidification system: Generally, it is dehumidified by freezing first, and then dehumidified by a runner. There are also dehumidification by freezing after a runner.
Large humidity difference treatment system: It is a two-stage series connection. After the fresh air is cooled, the dew point temperature can be reduced to 6~8 °C, and then the dew point can be reduced to about -10 °C through the first-stage rotary dehumidifier, and the dew point can be reduced to -20 through the second-stage rotary dehumidifier °C.
The following is an example of dehumidification in a GMP clean pharmaceutical cleanroom:
The following figure is a schematic diagram of the purification system of a chemical factory in the production base of Pioneermycin V and VI powder injection raw materials.
The project is divided into three production lines to produce aseptic powder of cephalosporins. Each production line has a drying process. After the products are dried in a vacuum drying oven, the materials are discharged into the drying room for packaging. The cleanliness of the drying room is grade 5. During the general working period, the temperature should be kept at 22℃±2℃, and the relative humidity should be maintained at 55%±10%; during the discharge period, the temperature should be less than 27℃, and the relative humidity should be less than or equal to 30%. The discharge time is about 3h.
Take the drying room in the picture as an example, the air treatment process is: 700
m3/h fresh air is mixed with a small amount of return air (2013m3/h), cooled by a surface cooler in the fresh air fan, dehumidified by a rotary dehumidifier, and then mixed with a large amount of return air (14927m3/h) in the circulating unit ) mixed and sent into the room with a total air volume of 17640m3/h.
When running, start the surface cooler of the fresh air unit first, and the system will reach the normal working state. At this time, the surface cooler of the rotary dehumidifier and the circulating unit will not work. Then provide steam with a pressure of 0.3MPa to the rotary dehumidifier. When the regeneration air temperature reaches 120~130℃, start the rotary dehumidifier and put it into work, and the system will turn into a dry state. Pay attention to maintaining the outlet water temperature of the fresh air surface cooler below 10°C. At this time, the room temperature gradually rises and the relative humidity drops; after 30~45min, the drying room reaches the required dry state.
Measurement results of temperature and relative humidity
Room name
Dry Bulb Temperature/°C
Wet Bulb Temperature/°C
Relative Humidity/%
Drying Room
24.8
25.5
27.4
13.9
14.2
15.0
26.5
25.0
23.0
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