Level 4 Biosafety Laboratory Requirements for Enclosures
Level 4 Biosafety Requirements for Enclosures
The four-level biological safety protection laboratory is divided into safety cabinet type laboratory and wearing positive pressure clothing type laboratory. In the safety cabinet type laboratory, all microbial operations are carried out in the Class III biological safety cabinet. In a positive pressure suit laboratory, staff must wear...
Text label: laboratory design and installation, biosafety laboratory, laboratory requirements
Level 4 Biosafety Requirements for Enclosures
The four-level biological safety protection laboratory is divided into safety cabinet type laboratory and wearing positive pressure clothing type laboratory. In the safety cabinet type laboratory, all microbial operations are carried out in the Class III biological safety cabinet. In the positive pressure suit type laboratory, the staff must wear special protective clothing of the positive pressure suit type; the core area of u200bu200bthe laboratory consists of a room with a Class III biological safety cabinet and an entry channel. The entry channel has at least three parts, in order of external Locker rooms, shower rooms and inner locker rooms have automatic interlocks between any adjacent doors to prevent two adjacent doors from being opened at the same time; for materials, items and equipment that cannot be brought into or out of the locker room from the locker room , an autoclave with a double-door structure should be installed on the wall of the safety cabinet, and there should be a soaking disinfection tank, a fumigation room or a ventilation transfer window with a disinfection device for transfer or disinfection; an airlock room must be installed A buffer zone can be set up around the safety cabinet, which is a ring corridor or a buffer room, which is part of the core area. The construction requirements of the buffer zone are the same as those of the third-level biosafety protection laboratory.
The walls, floors and ceilings of the safety cabinet room and the inner dressing room should form a sealed inner shell, the floor should be sealed as a whole, the corners should be arc-shaped, and the inner surface of the room should be waterproof and corrosion-resistant; The gaps should be sealed, and the gaps around the doors of the safety cabinet and the inner locker room should be minimized and sealed to facilitate disinfection; the door to the pharma machinery can be automatically closed and locked, and all equipment for passing items inside and outside the laboratory must be It is a double door structure, and there must also be an automatic interlocking device between the two doors; any window must be broken and sealed; it is installed on the wall hole of the laboratory to carry out inspection on the items passed from the Class III biological safety cabinet and the safety cabinet. Sterilized double-door autoclave, the outer door of which is opened outside the laboratory, and the gap must be well sealed. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for biosafety laboratories and clean rooms.
A well-designed and constructed in-line ventilation system must be installed. The air intake and exhaust design of the system should ensure that the directional airflow flows from the least dangerous area to the greatest potential danger area. The layout of the air intake and exhaust should be such that the experimental area The internal space is reduced to a minimum; the pressure difference and airflow direction of the adjacent areas must be monitored, and an alarm should be installed, and a pressure instrument panel should be installed at the entrance of the outer dressing room to display and monitor the pressure or pressure difference and inlet pressure of each area in the laboratory. Air, exhaust air and air volume; automatic control and alarm devices for ventilation systems must be designed and installed to ensure that there is no positive pressure in the laboratory and to maintain normal pressure and pressure difference in each room. The exhaust air of the Class III biological safety cabinet must be directly connected to the exhaust air. The pipes are connected, and the exhaust pipes must be set up separately and shall not be connected with the building exhaust system. The exhaust air from the entire core area must be continuously processed by two high-efficiency filters, and the air outlet should be far away from the laboratory area and the air inlet; the air inlet and exhaust high-efficiency filters must be installed in each room of the laboratory on the enclosure structure In order to avoid contamination of the air duct, the structure of the high-efficiency filter tuyere must be sterilized on site before replacing the high-efficiency filter, or a filter structure that can be replaced in an air-tight bag; each high-efficiency filter is installed before and after. Testing must be carried out and once a year after operation.
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