Each clean room in the clean area maintains a positive differential pressure differential air volume, which needs to be supplemented by outdoor fresh air. Therefore, the size of the positive pressure difference air volume in the clean room directly affects the fresh air ratio of the purification air conditioning system and the energy consumption of the purification air conditioning system. Each clean room in the clean area maintains the air volume of the negative pressure difference, which infiltrates into the clean room from the outside of the clean room. In many cases, it is the unpurified outdoor air. The cleanliness of the negative pressure clean room. At present, the common methods for calculating the pressure difference and air volume of the clean room include the gap method and the number of air changes. The gap method is to estimate the pressure difference and air volume of the clean room based on the total length of the gaps such as doors and windows in the clean room. However, in practical applications, the work of counting the number of gaps such as doors and windows is cumbersome and prone to errors, so it is rarely used at present. The number of air changes method is to estimate the pressure difference air volume of the clean room according to the number of air changes in the clean room. In actual engineering, it is entirely possible to reduce the room pressure difference and air volume by strengthening the airtightness of the clean room enclosure structure. According to the pressure difference value of the clean room, the pressure difference air volume should be selected according to the number of air changes of 1-2 times/hour. The easiest way is to adjust the direction opening size of the return air vent grille first, first determine the air supply volume and return air volume, and firstly, under the premise that the wind speed and air volume are satisfied, you can adjust the opening size of the return air vent and the filter cloth to see if the requirements can be met. If not, you can only adjust the air valve size of the high-efficiency outlet of each clean room on the interlayer of the workshop, but pay attention to the adjustment, which will affect the air volume of other rooms. If there are too many high-efficiency ports, it is best to test the wind speed and air volume after the adjustment. Then adjust the regulating valve of the high-efficiency filter air supply cylinder, first increase the cleanliness level and then lower the cleanliness level, so that the pressure difference in each room meets the gmp requirements. Note that when adjusting the air valve, it is necessary to ensure that the performance of the high-efficiency filter meets the requirements.

Suzhou Pharma Machinery Co.,Ltd.

2023/05/17

Birkey