GMP workshop solid-liquid extraction method and process

GMP workshop solid-liquid extraction method and process

The extraction in the GMP pharmaceutical cleanroom is based on the nature of the solvent, part, dosage form, process conditions and production scale, and different extraction methods are used. The commonly used methods include decoction, immersion, percolation and reflux. . The impregnation method is to use a quantitative solvent in a selected...

Text label: GMP workshop solid-liquid extraction method, solid-liquid extraction process, GMP workshop plant installation manufacturer

Method and process of solid-liquid extraction in GMP workshop

The extraction in the GMP workshop is based on the nature of the solvent, part, dosage form, process conditions and production scale, and different extraction methods are used. The commonly used methods include decoction, immersion, percolation and reflux. . The dipping method is to use a quantitative solvent to soak the pieces or granules for a certain period of time at a selected temperature to extract the components. The warm impregnation method operates at 40-60°C and the hot impregnation method operates below the boiling point by heating. The reflux method is to extract the components from the pieces or coarse powder with a volatile organic solvent. During the extraction process, the evaporated volatile solvent vapor is condensed and then returned to the extractor for repeated use until the effective components are fully leached. According to the different extraction process temperature, it can be roughly divided into reflux cold extraction method operated at room temperature, reflux warm extraction method heated at 40-60°C and reflux hot extraction method heated below the boiling point.

Extraction equipment can be divided into intermittent extraction equipment and continuous extraction equipment. According to the movement state of solid materials in the extractor, it can also be divided into static extraction equipment and dynamic extraction equipment; static extraction equipment is usually in the extraction tank. , the extraction of solids is basically in static state. Commonly used methods are single-stage extraction, Soxhlet extraction and tank group extraction. Dynamic extraction includes dynamic intermittent extraction and dynamic continuous extraction. Dynamic intermittent extraction includes forced external circulation extraction. Extraction, stirring extraction, etc. Dynamic continuous extraction includes screw-propelled continuous extraction, crawler-type continuous extraction, etc. The dipping equipment is mainly used for dipping extraction. A certain amount of cut or pulverized raw materials are placed in the leacher, and a certain amount of solvent is injected to make the solid-liquid contact. After a certain period of time, the extraction components are fully dissolved, and then The liquid and slag are separated by means of the false bottom of the extractor and filter cloth or other methods. In order to strengthen the impregnation, the impregnator can be equipped with machinery such as agitators, pumps and heating devices, such as jackets or coils. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for GMP workshops and GMP workshops.

The multi-energy extraction process consists of extraction tank, condenser, cooler, oil-water separator and residue filter. The jacket of the extraction tank is heated by steam. The aromatic oil can be separated out, or directly returned to the tank, which can be used for immersion, warm immersion, hot reflux, etc. After the residue filter, the material liquid can be pumped back to the original tank with a pump, and the extraction liquid can be recycled. The clarity of the hot reflux leachate is relatively high. Poor, due to factors such as high temperature, inactive ingredients are also easily leached, and are generally used in solid oral preparations. The combined device of extraction and solvent recovery is often used in pharmaceutical production, which makes the equipment compact and continuous. During the working process, the recovered solvent flows from the recovery solvent reservoir into the extraction tank, and this cycle is repeated until the components to be extracted in the material are basically recovered. Clean up. The feeding, slag discharge and extraction liquid collection of the continuous extractor can be carried out continuously, the extraction efficiency is high, the extraction rate is fast, and the degree of automation is high.

SUZHOU PHARMA MACHINERY CO.,LTD. has built its reputation on a commitment to providing quality products and services while rapidly responding to international needs for innovative products.

Our knowledgeable loss prevention experts can help commercial customers reduce losses in CUSTOM SOLUTION SERVICES.

Always put quality over cost is the rule of thumb if you want to buy a really durable and reliable . But with SUZHOU PHARMA MACHINERY CO.,LTD., you can have the same.