GMP dust-free purification workshop fermentation equipment

GMP dust-free purification workshop fermentation equipment

The fermentation equipment in the GMP purification workshop is the main equipment in the fermentation plant. It provides a place to adapt to the life activities and biological metabolism of microorganisms. The volume, gas, liquid, temperature, heat exchange and PH adjustment of the fermentation process and the fermentation equipment It has a lot to do with anaerobic or...

Text label: GMP dust-free purification pharmaceutical cleanroom, fermentation equipment, design, installation and construction

GMP dust-free purification workshop fermentation equipment

The fermentation equipment in the GMP purification pharmaceutical cleanroom is the main equipment in the fermentation plant. It provides a place to adapt to the life activities and biological metabolism of microorganisms. The volume, gas, liquid, temperature, heat exchange and PH adjustment of the fermentation process and the fermentation equipment It has a lot to do with anaerobic or ventilated fermentation equipment, in addition to meeting the necessary process requirements for microbial culture, factors such as material requirements and the difficulty of processing and manufacturing must also be considered; the fermentation operation in the pharmaceutical industry includes intermittent operation and continuous operation. and semi-continuous operation, but mainly intermittent operation. Intermittent operation usually uses a fermentation kettle, which is characterized by adding the required raw materials into the fermentation kettle at one time. After completing the specified fermentation process, all materials are taken out, and the kettle is cleaned. The whole process It is feeding-fermenting-discharging-cleaning; when using the fermentation kettle, attention should be paid to avoiding the use of metallic copper in the pipeline and valve system in the kettle to prevent copper ions from inhibiting the growth of microorganisms and reducing the extraction rate of finished and semi-finished products; the kettle should have a suitable temperature and the corresponding strength to facilitate the normal growth of microorganisms; increase the defoaming device to avoid the generation of foam; the inner wall of the kettle should be smooth, and the fewer internal accessories, the better, which is conducive to thorough sterilization before feeding.

In the process of aerobic fermentation, the continuous introduction of air is required to supply the oxygen required for the growth of microorganisms. The faster the dissolution, the more commonly used types of ventilated fermenters: mechanically stirred fermenters, self-priming fermenters, airlift fermenters, and venturi fermenters. A good mechanical fermentation tank should have a suitable ratio of diameter to height. The ratio of height to diameter of the fermentation tank is generally 1.7-4. The longer the tank body, the higher the utilization rate of oxygen; the fermentation tank can withstand a certain pressure; the stirring ventilation device The gas and liquid can be fully mixed to ensure the dissolved oxygen of the fermentation liquid; the fermentation tank should have sufficient cooling area; the dead angle should be minimized in the fermentation tank to avoid accumulation of dirt and dirt, and the sterilization can be completed; the shaft seal of the stirrer should be tight. Minimize leaks. The main components of the mechanically stirred fermentation tank include: tank body, shaft seal, agitator, coupling, intermediate bearing, baffle, air branch pipe, heat exchange device and pipeline, etc. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for GMP purification workshops and dust-free workshops.

In the continuous fermentation tank, when the material is continuously added, due to the vigorous stirring of the agitator, some of the materials that should leave the fermentation tank are rolled back and remain in the fermentation tank, and some of the newly added materials will not be able to ferment in the future. It flows out of the fermenter; the disadvantage of the kettle type fermenter is that it is cumbersome and consumes a lot of energy during stirring. Multiple kettles are connected in series to form a cylindrical tower body, and in order to reduce the phenomenon of back-mixing short circuit, in the tower body Install baffles and fillers in the middle, so that the fermenter is a tower fermenter; the more the number of fermentation tanks in series, the higher the volumetric efficiency, when the number of fermentation tanks is constant, the higher the conversion rate, the lower the volumetric efficiency; The large length-diameter ratio of the equipment and the increase of the linear speed of the fermented material through the fermenter constitute a tubular fermenter; the tubular fermenter has a simple structure, is easy to process, manufacture and maintain, and the metal pipe can withstand high pressure and can be used for pressurized fermentation. It is used for the fermentation of gas phase, homogeneous liquid phase, heterogeneous liquid phase, gas-liquid phase, liquid-solid phase and solid phase. Due to the limitation of tower height and tube length, the residence time of the fermented product in the tower fermenter or tube fermenter cannot be too long, so this method should not be used for substances with slow fermentation speed and long reaction time, but batch fermentation should be used. Can production.

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