Dust-free laboratory layout enclosure, air conditioning system requirements?
Dust-free laboratory layout enclosure, air conditioning system requirements?
BSL-3 dust-free laboratory should be a self-contained area or an independent building in the building, and there should be strict restrictions and controls on personnel access; the auxiliary work area and the protection area should be clearly distinguished, and the direct work in the protection area should be The high-risk operation workshop is the core pharmaceutical cleanroom,...
Text label: dust-free laboratory layout enclosure, laboratory air conditioning system requirements
Clean laboratory layout and enclosure, air conditioning system requirements?
BSL-3 dust-free laboratory should be a self-contained area or an independent building in the building, and there should be strict restrictions and controls on personnel access; the auxiliary work area and the protection area should be clearly distinguished, and the direct work in the protection area should be The workroom for high-risk operations is the core workroom, and personnel should enter the core workroom through the buffer room; the auxiliary work area of u200bu200bthe laboratory should at least include the monitoring room and the changing room for cleaning clothes, and the protection area should at least include the buffer room and the core workroom; Install the transfer window as needed, and its structural pressure and airtightness should meet the requirements of the area where it is located to ensure the integrity of the enclosure structure, and should have the conditions to sterilize the surfaces of the items in the transfer window; full consideration should be given to biological safety cabinets, For large equipment such as double-door pressure steam sterilizers to enter and exit the laboratory, the laboratory should be equipped with equipment doors of sufficient size.
The inner surface of the enclosure structure in the laboratory protection area should be smooth, corrosion-resistant, non-cracking, and waterproof. All gaps and joints at penetrations should be reliably sealed, and should be easy to clean and disinfect; the ground in the protection area should be Anti-leakage, complete, smooth, non-slip, corrosion-resistant, and dust-free; all indoor doors should be able to close automatically, and observation windows should be provided when necessary; all windows should be airtight, and the glass should be impact-resistant and break-proof; The height of the room and the equipment room should meet the installation requirements of the equipment, and there should be maintenance and cleaning space; under the normal operation of the ventilation system, when the tightness of the enclosure structure in the laboratory protection area is checked by the smoke test method, all gaps should be free. Visible leakage; no access openings, etc. shall be set on the ceiling of the laboratory protection area. An independent pharma machinery air supply and exhaust system should be installed to ensure that the airflow flows from the low-risk area to the high-wind direction area during operation, and at the same time to ensure that the air is filtered through the HEPA filter and discharged to the outside; the design of the pharma machinery air conditioning system should fully consider the biological safety cabinet , centrifuges, carbon dioxide incubators, refrigerators, pressure steam sterilizers, emergency spray devices and other equipment cold, heat and humidity loads; the arrangement of air supply and exhaust vents in the room in the laboratory protection area should comply with the principle of directional airflow , the air supply and exhaust should not affect the normal functions of other equipment, and no air supply should be set above the operating surface of the biological safety cabinet or other aerosol occurrence sites. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for laboratories and sterile rooms.
The biological safety cabinet and its exhaust duct system should be installed according to the design requirements and instructions of the product; the air discharged from the laboratory protection area shall not be recycled, and the split air conditioner shall not be installed in the laboratory protection area for indoor circulation treatment Air equipment; the air supply should be filtered by primary, medium and HEPA filters; the outdoor air outlet of the laboratory protection area should be set in the downwind direction of the dominant wind, and the straight-line distance from the new air outlet should be greater than 12m, and it should be It is more than 2m above the roof of the building where it is located, and it should be designed to prevent wind, rain, rodents and insects, but it should not affect the discharge of gas to the air; the installation position of the HEPA filter should be as close as possible to the air supply and exhaust ducts; if When using a high-efficiency air filter unit outside the laboratory protection area, its structure should be firm, and it should be able to withstand a pressure of 2500pa. The overall sealing performance of the high-efficiency air filter unit should be able to close all passages and maintain the temperature in the chamber. Stable conditions If the air pressure is maintained at 1000pa, the amount of air leaking in the chamber per minute should not exceed 0.1% of the net volume of the chamber; the exhaust duct of the laboratory should be made of corrosion-resistant, aging-resistant and non-absorbent materials. Using stainless steel pipes, the air supply pipes and exhaust pipes connecting the airtight valve to the laboratory protection area should be firm and airtight. When the pressure is maintained at 500pa, the amount of air leaked in the pipeline per minute should not exceed 0.2% of the net dissolved volume in the pipeline; one exhaust fan should be used and one backup should be used, and the length of the positive pressure section of the exhaust duct behind the exhaust fan should be minimized.
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