Controlling Air Quality in Clean Rooms: A Comprehensive Approach

In general, it is necessary to choose a suitable cleanroom design, conduct regular maintenance and upkeep, and do a good job of daily monitoring. Special attention should be paid to the monitoring of planktonic bacteria in pharmaceutical cleanrooms. The planktonic bacteria in the space are sampled with a planktonic bacteria sampler to extract a certain volume of air from the space. The airflow passes through a contact dish filled with a specific culture medium, and the contact dish captures the microorganisms. Then, the dish is placed in an incubator to culture and count the number of bacterial colonies, and the number of microorganisms in the space is calculated. The microorganisms in the laminar layer also need to be detected, using the corresponding laminar layer planktonic bacteria sampling instrument. The working principle is similar to spatial sampling, but the sampling points need to be placed in the laminar layer. If compressed gas is required in the sterile room, it is also necessary to perform microbiological testing on the compressed air. To use the corresponding compressed air detector, the pressure of the compressed gas needs to be adjusted to a suitable range first to prevent damage to microorganisms and culture media.

In addition, the control of air temperature and humidity in class 100 clean room is also crucial. Appropriate temperature and humidity not only provide a comfortable working environment for workers, but also affect the growth and reproduction of microorganisms. For industries with strict temperature and humidity requirements, such as electronic chip manufacturing, even small changes in temperature and humidity can affect the quality and performance of products. Therefore, precise temperature and humidity control equipment should be installed and regularly calibrated and maintained to ensure its normal operation.

At the same time, the velocity and direction of air flow are also key points that need to be paid attention to. Reasonable airflow organization can effectively eliminate pollutants and prevent cross contamination. By installing efficient air filters and ventilation systems, ensure that the air flows at the correct speed and direction to maintain the air quality in the clean room.

In daily monitoring, in addition to microbiological testing, it should also include particle detection, pressure difference monitoring, etc. Particle detection can help us understand the number of dust particles in the air, while pressure difference monitoring can ensure that the pressure gradient between different areas is normal, preventing pollutants from spreading from high-pressure areas to low-pressure areas.

Suzhou Pharma Machinery Co.,Ltd.

2025/03/03

Mia