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Clean room air purification measures

by:PHARMA     2022-09-25

Using clean room technology to control the pollution of the controlled microenvironment to achieve the required air cleanliness requires a variety of comprehensive technical measures. These measures include: 1. The use of composite materials to build clean rooms The pollution control of clean rooms is a systematic project, which requires the effective cooperation of various measures to achieve the most effective pollution control at the least cost. The walls, floors and ceilings of the clean room should be free of dust, less dust, not easy to breed bacteria, have no joints or few joints, and the joints should be tight. The materials that meet the requirements include color steel sandwich composite panels, electrolytic steel plates with antibacterial coatings, artificial stone panels, etc. Floor materials: epoxy resin self-leveling floor, PVC anti-static floor, advanced terrazzo floor, etc. 2. The selection of pharma machinery that meets the requirements of the clean room is done by the craftsman. The current situation is: a considerable proportion of the process equipment does not meet the requirements of the clean room, which is uneven, easy to generate dust and accumulate dust, and pollute the environment. After the equipment is installed, without affecting the use, it can be decorated with stainless steel plate to make the surface smooth and clean. 3. Adopt differential pressure control measures According to the level of cleanliness and the dust production of process pharma machinery, use differential pressure to effectively control pollution. In general, the airflow should flow from a clean room with high cleanliness to a clean room with low cleanliness. For clean rooms that produce pollution, in addition to taking measures to prevent the spread of pollution, the clean room should be in a state of relatively negative pressure to prevent contamination of adjacent rooms. 4. Adopt reasonable human and material purification measures to cooperate with professional architectural design, rationally design the flow of people and logistics channels, and adopt one-, two- or even three-shift human-cleaning schemes according to process requirements. If necessary, an air shower room should be set up to clean the floating dust on the work clothes. The input of raw materials and the output of products require good protection measures. Such as setting transfer window, transfer channel. Carry out outsourced vacuuming, decontracting and other processes for the input raw and auxiliary materials. The airflow direction of the input and output ports is controlled by the differential pressure, and the static pressure in the clean area should be 15Pa higher than that in the clean area. 5. The use of airflow organization that meets the requirements of cleanliness is the core measure of air purification. Use the method of filtration (at least three levels: coarse, medium, high or sub-efficient) to make the supply air flow clean. In the non-unidirectional flow clean room, by reasonably arranging the air supply and return air, the pollutants are diluted and discharged from the return air by the diffusion and dilution of the clean air supply. Maintain pharma clean room aerosol concentrations within the required range. In the one-way flow clean room, the contaminants are 'pressed' out from the return air outlet by the 'piston'-like push action of the clean supply air flow. The production of some products requires precision and high purity. In addition to controlling the pollution in the microenvironment, it is also necessary to control its molecular pollution. To this end, chemical filters, adsorption filters and absorption devices should also be provided in the air handling systems of these clean rooms. The design of the dust-free aseptic pharmaceutical cleanroom is to find Guangdong Saite, to provide you with professional design and high-quality after-sales service.
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