Cleanroom Construction Key Points-Not Easy Following

Cleanroom construction is never as simple as "following the blueprints"—it demands more expertise than design and is more rigorous than ordinary factory construction. From the millimeter-level precision of leveling the base layer to the sealing control of duct installation, and the parameter calibration of the purification system, any oversight in construction details can not only lead to substandard cleanliness and acceptance failure, but also leave hidden dangers for later operation, causing rectification losses of hundreds of thousands or even millions.

Pre-construction Preparation – Standard Control is a Prerequisite (Eliminating "Inherent Defects") In cleanroom construction, "inadequate preparation leads to complete waste later." Many construction teams rush to meet deadlines, skipping preliminary steps such as benchmark confirmation, site cleanup, and personnel training, and directly begin construction. This often results in inherent defects such as tilted walls, uneven floors, and system incompatibility, making subsequent rectification extremely difficult. Key Construction Preparation Points (with Measured Data): Benchmark Verification: Verify site elevation and axis deviations against design drawings. Deviations must be controlled within ≤3mm, especially at the boundaries between clean and buffer zones and non-clean areas, where elevation errors must not exceed 2mm to avoid pressure differential control failure later. Site Cleanup: Remove dust, debris, and oil stains from the construction site. Pre-treat the ground flatness; height difference ≤5mm/2m. Otherwise, leveling is required beforehand to prevent sanding and cracking of the epoxy flooring later. Personnel Training: All construction personnel (HVAC, plumbing, carpentry) must undergo cleanroom construction training, understand construction specifications, and wear dust-proof clothing and shoes when entering the construction area. Bringing dust-laden items into the site is prohibited. Material Sampling Inspection: Core materials such as color steel plates, filters, and sealants must be sampled on-site. Color steel plate flatness ≤0.3mm/m, and sealant mold resistance level must reach 0. Unqualified materials must be immediately removed from the site to prevent the use of inferior materials.

The enclosure structure of a cleanroom (walls, ceiling, doors and windows) is the "first line of defense against dust." The core construction principle is "seamless, no protrusions, and easy to clean." Once gaps or rough surfaces appear, dust easily accumulates and leaks, making it impossible to achieve the required cleanliness even with the best purification system. Key construction points (with measured data and standard references): Steel panel installation: Use tongue-and-groove splicing, with joint gaps ≤0.5mm. Sealant must be continuously applied at the joints, with a joint width of 5-8mm and a thickness of 3-5mm. There should be no gaps or air bubbles. After installation, the wall verticality should be ≤2mm/m, and the ceiling flatness ≤3mm/m. Door and window installation: Cleanroom doors should be airtight steel doors, with gaps between the door frame and the wall ≤1mm. After installation, they should open and close smoothly with good airtightness, and the air leakage rate should be ≤0.1m³/(m·h). Observation The windows use double-glazed tempered glass, with a tight seal between the glass and the frame, preventing light and air leakage. For joint treatment: At the junctions of walls, floors, and ceilings, a rounded transition (radius ≥ 50mm) is used to avoid dust accumulation at right angles. Sealant is continuously applied at these transitions, leaving no dead corners. Where pipes pass through walls and ceilings, a double treatment of sealant and fireproofing is used to ensure a tight seal and prevent air and dust leaks. Prohibited operations: Drilling or nailing on the color steel panels is prohibited. Ordinary wood and plastering materials must not be brought into the cleanroom enclosure for construction to avoid dust accumulation and powdering.

The cleanroom floor must not only be flat, wear-resistant, and easy to clean, but also meet industry requirements for anti-static and corrosion resistance. Construction precision directly affects later use. For example, in the electronics industry, excessive resistance in anti-static floors can damage chips, while in the pharmaceutical industry, sandy epoxy floors can lead to microbial growth. Construction guidelines for different floor types (with measured data): Epoxy self-leveling floor (suitable for ISO 5-7): The substrate needs to be sanded smooth, with a moisture content ≤8%. After applying the primer, lay the intermediate and top coats, with a thickness of 2-3mm. The flatness should be ≤0.2mm/m, and the abrasion resistance ≥300mg/1000 revolutions. For anti-static flooring, the surface resistance should be controlled at 10⁶-10⁹Ω. Curing should be completed for at least 72 hours after construction; premature walking is prohibited. Anti-static PVC flooring (suitable for ISO 5-7): Levels 7-8): Base layer flatness ≤ 0.3mm/m, hot-melt welding, weld width 10-15mm, welding strength ≥ 0.8 times the strength of the base material, surface resistance 10⁶-10⁹Ω, no bubbles, no delamination; Connection between floor and wall: use arc transition, transition radius ≥ 50mm, sealant applied densely, without gaps, to avoid dust and water accumulation, especially in medical sterile areas and food clean areas, to prevent water stains from seeping into gaps and breeding microorganisms.

Suzhou Pharma Machinery Co.,Ltd.

2026/04/24

Gino