Modular cleanrooms are essential facilities used in industries such as pharmaceuticals, electronics, and medical devices manufacturing, where a sterile environment is required. Keeping the modular cleanroom in pristine condition is crucial for the success of any manufacturing process. In this article, we will discuss three steps for modular cleanroom maintenance and upkeep.

Step 1: Regular Cleaning

The first step in maintaining a modular cleanroom is regular cleaning. Cleanrooms must be cleaned on a regular basis to ensure that they remain free from contaminants. Regular cleaning should be performed daily, weekly, monthly, and annually, depending on the level of cleanliness required and the type of manufacturing process being carried out.

The cleaning process should be thorough and consistent. The walls, floors, and ceilings should be cleaned using specialized cleaning solutions that are designed for cleanroom environments. The cleaning process should include disinfecting surfaces, wiping down equipment, and removing any debris.

Step 2: Air Filter Maintenance

Air filters are crucial components of a modular cleanroom, as they help to keep the air free from contaminants. Regular maintenance of air filters is essential to ensure their function properly. Filters should be inspected and replaced on a regular basis to prevent the buildup of contaminants that will damage the integrity of the cleanroom.

The frequency of filter replacement will depend on the level of cleanliness required and the type of manufacturing process being carried out. The replacement schedule should be established based on the manufacturer's recommendations and the results of regular air quality testing.

Step 3: Monitoring and Testing

The final step in maintaining a modular cleanroom is monitoring and testing. Regular monitoring and testing of the cleanroom environment are essential to ensure that it remains free from contaminants. Environmental monitoring should include the measurement of temperature, humidity, and air pressure. Additionally, regular testing should be performed to ensure that the air quality meets the required standards.

In the event of a deviation from the required standards, corrective action should be taken immediately to prevent any contamination from occurring. Corrective action can include shutting down the cleanroom, identifying the source of contamination, and implementing measures to prevent the recurrence of the issue.

In conclusion, the maintenance and upkeep of modular cleanroom are essential to ensure that the cleanroom remains free from contaminants and the functions properly. Regular cleaning, air filter maintenance, and monitoring and testing are three essential steps that should be taken to maintain a modular cleanroom. By following these steps, manufacturers can ensure that their products meet the highest quality standards and are safe for use.

 

 

Suzhou Pharma Machinery Co.,Ltd.

2023/03/26

Mia

 

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Layout and construction of ointment production purification pharmaceutical cleanroom

The production process of ointment includes: matrix preparation, mixing preparation, filling, boxing, labeling, boxing, finished product inspection, etc.
, the process is slightly different; the configuration equipment includes heating tank, batching tank, conveying pump, emulsification, mixing equipment and paste making machine, etc.; soft...
Text label: ointment production purification pharmaceutical cleanroom, purification workshop layout construction

Layout and construction of ointment production and purification pharmaceutical cleanroom


The production process of ointment includes: matrix preparation, mixing preparation, filling, boxing, labeling, boxing, finished product inspection, etc.
, the process is slightly different; the configuration equipment includes heating tank, batching tank, conveying pump, emulsification, mixing equipment and ointment machine, etc.; ointment has strict requirements on the hose used for filling, hose material and ointment base No physical and chemical effects, no back suction after extrusion, the inner wall of the tube should be clean, the tube wall should be airtight, the outer wall of the tube can be easily painted with brightly colored patterns and trademarks, and it is not easy to fall off; the commonly used hoses are Coated aluminum pipes, plastic pipes and composite pipes on the inner wall.


The ointment base needs to be fully heated, kept warm and stirred during the preparation process to ensure complete melting of the base. It needs to use a batching tank. The stirring system consists of a motor, a reducer, a stirrer, etc.; the jacket of the batching tank is It can be heated by hot water or steam. When using hot water for heating, according to the principle of convection, the drain valve is installed at the upper part, the water inlet valve is installed at the bottom of the equipment, and the air release valve is installed at the high position of the jacket to prevent the top gas from causing damage. Reduce the heat transfer effect; the stirrer shaft passes through the sealing ring installed at the lid of the pot, in addition to maintaining the vacuum or pressure in the sealed tank, the sealing ring can also prevent the lubricating oil of the transmission system from being polluted, which is convenient for the in and out of the material in the pot; use a vacuum When discharging, the nozzle extends into the bottom of the equipment, and vacuum feeding is used to prevent the volatilization of raw materials; due to the high viscosity of the paste, the inner wall of the batching tank needs to be smooth, and the stirring paddle is framed, and the shape is as close to the inner wall as possible. Generally, for high-viscosity substrates or ointments with high solid content, in order to make the stirring quality high, a circulating pump is often used to carry the material to the outside of the pot to circulate, so as to help the material to turn up and down in the tank and achieve the purpose of stirring evenly. The commonly used colloid conveying pump and stainless steel gear pump. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for purification workshops and sterile workshops.














There are requirements for solid particle size in external ointment. In order to make the ointment base and the drug mix evenly and delicately, and apply on the skin or mucous membrane without irritation, usually after the ingredients are added, the drug needs to be further ground, crushed and mixed evenly. The types of equipment used here are stone mill, ball mill, three-roll mill, colloid mill, emulsifier, etc.
, among which colloid mill is more advanced; colloid mill is composed of upper and lower grinders, with a mill that can precisely control the distance between grinding surfaces, mainly composed of rotor and stator; The gap flows through, depending on the high-speed relative rotation of the two cone surfaces, so that the paste will generate vortex and high-frequency vibration under the action of great friction, shear force and centrifugal force, so that the paste will be crushed and play a very good role. Mixing, homogenizing and emulsification. In the preparation process of ointment, the paste making machine is the key equipment in the configuration process. All materials need to be uniformly stirred, heated and emulsified by the paste making machine. Therefore, the mixer is required to have good performance, convenient operation and easy cleaning. Delicate, smooth and consistent quality ointment.
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1. What is coronavirus and novel coronavirus? Coronaviruses are a large group of viruses known to cause illness in patients ranging from the common cold to severe lung infections such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). A novel coronavirus (nCoV) is a new type of coronavirus that has not been identified in humans before, such as the novel coronavirus 2019-nCov in Wuhan, China. 2. What are the symptoms of a person infected with the coronavirus? Symptoms of infection depend on the type of virus and the patient's own physical state, but common symptoms include respiratory symptoms, fever, cough, shortness of breath, and difficulty breathing. In more severe cases, the infection can lead to pneumonia, severe acute respiratory syndrome, kidney failure and even death. 3. Can the coronavirus spread from person to person? There is human-to-human transmission of the new coronavirus, and there is an incubation period for human-to-human transmission. The incubation period of the onset varies according to the length of the individual's constitution, it may be 3 to 7 days, and generally no more than 14 days. 4. Is there a vaccine against the new coronavirus? Emerging diseases take time to develop a vaccine for, and developing a new vaccine can take years. 5. Is there a cure for the novel coronavirus? There is no specific treatment for the disease caused by the novel coronavirus. However, many of the symptoms are treatable, so treatment can be tailored to the patient's clinical condition. Also, supportive care for infected people can be very effective. 6. Are healthcare workers more at risk? Yes, because health care workers have more frequent contact with patients than the general public and are more at risk of infection with the novel coronavirus, WHO recommends that health care workers always take appropriate infection prevention and control measures. 7. What can I do to protect myself? Standard recommendations for reducing exposure and transmission of multiple diseases include maintaining basic hand and respiratory hygiene, as well as safe eating habits, and, when possible, avoiding close contact with people exhibiting symptoms of respiratory illness, such as coughing and sneezing . 8. What mask should I wear? Patients with respiratory infectious diseases should wear medical non-woven masks to prevent the spread of viruses or bacteria in their bodies to the outside world, thereby protecting healthy people around them, and healthy people who are in close contact with them should wear N95 masks to prevent themselves from being infected. However, N95 masks are more expensive. During the epidemic period of infectious diseases, the outdoor virus concentration is low. Healthy people can choose medical non-woven masks for infectious disease prevention and control. Precautions for wearing a mask 1. In order to better play the protective effect of the mask, try to tighten the elastic band of the mask when wearing the mask, and compress the aluminum sheets on both sides of the nose to reduce leakage around, and it is best to breathe slowly. 2. The wearing time should be appropriate. Medical non-woven masks can be used continuously for 6-8 hours, and should be replaced in time in the following situations: breathing difficulties, the mask is damaged or destroyed; the mask cannot be tightly attached to the face, and the mask is contaminated (for example, when it is stained with foreign objects such as blood stains or droplets) , It has been used in isolation wards or in contact with patients, and it has peculiar smell. 3. Never squeeze the mask with your hands after wearing it. All kinds of masks, including N95 masks, can only isolate the virus on the surface of the mask. If you squeeze the mask with your hands, the virus will soak through the mask with the droplets, and there is still a chance to infect the virus. 4. Do not discard discarded masks at will, otherwise it will cause secondary pollution. The masks used in the general environment should be put into the trash can, and the masks used to pollute the environment should be disposed of harmlessly as hazardous wastes.