Layout and construction of ointment production purification workshop
Layout and construction of ointment production purification pharmaceutical cleanroom
The production process of ointment includes: matrix preparation, mixing preparation, filling, boxing, labeling, boxing, finished product inspection, etc.
, the process is slightly different; the configuration equipment includes heating tank, batching tank, conveying pump, emulsification, mixing equipment and paste making machine, etc.; soft...
Text label: ointment production purification pharmaceutical cleanroom, purification workshop layout construction
Layout and construction of ointment production and purification pharmaceutical cleanroom
The production process of ointment includes: matrix preparation, mixing preparation, filling, boxing, labeling, boxing, finished product inspection, etc.
, the process is slightly different; the configuration equipment includes heating tank, batching tank, conveying pump, emulsification, mixing equipment and ointment machine, etc.; ointment has strict requirements on the hose used for filling, hose material and ointment base No physical and chemical effects, no back suction after extrusion, the inner wall of the tube should be clean, the tube wall should be airtight, the outer wall of the tube can be easily painted with brightly colored patterns and trademarks, and it is not easy to fall off; the commonly used hoses are Coated aluminum pipes, plastic pipes and composite pipes on the inner wall.
The ointment base needs to be fully heated, kept warm and stirred during the preparation process to ensure complete melting of the base. It needs to use a batching tank. The stirring system consists of a motor, a reducer, a stirrer, etc.; the jacket of the batching tank is It can be heated by hot water or steam. When using hot water for heating, according to the principle of convection, the drain valve is installed at the upper part, the water inlet valve is installed at the bottom of the equipment, and the air release valve is installed at the high position of the jacket to prevent the top gas from causing damage. Reduce the heat transfer effect; the stirrer shaft passes through the sealing ring installed at the lid of the pot, in addition to maintaining the vacuum or pressure in the sealed tank, the sealing ring can also prevent the lubricating oil of the transmission system from being polluted, which is convenient for the in and out of the material in the pot; use a vacuum When discharging, the nozzle extends into the bottom of the equipment, and vacuum feeding is used to prevent the volatilization of raw materials; due to the high viscosity of the paste, the inner wall of the batching tank needs to be smooth, and the stirring paddle is framed, and the shape is as close to the inner wall as possible. Generally, for high-viscosity substrates or ointments with high solid content, in order to make the stirring quality high, a circulating pump is often used to carry the material to the outside of the pot to circulate, so as to help the material to turn up and down in the tank and achieve the purpose of stirring evenly. The commonly used colloid conveying pump and stainless steel gear pump. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for purification workshops and sterile workshops.
There are requirements for solid particle size in external ointment. In order to make the ointment base and the drug mix evenly and delicately, and apply on the skin or mucous membrane without irritation, usually after the ingredients are added, the drug needs to be further ground, crushed and mixed evenly. The types of equipment used here are stone mill, ball mill, three-roll mill, colloid mill, emulsifier, etc.
, among which colloid mill is more advanced; colloid mill is composed of upper and lower grinders, with a mill that can precisely control the distance between grinding surfaces, mainly composed of rotor and stator; The gap flows through, depending on the high-speed relative rotation of the two cone surfaces, so that the paste will generate vortex and high-frequency vibration under the action of great friction, shear force and centrifugal force, so that the paste will be crushed and play a very good role. Mixing, homogenizing and emulsification. In the preparation process of ointment, the paste making machine is the key equipment in the configuration process. All materials need to be uniformly stirred, heated and emulsified by the paste making machine. Therefore, the mixer is required to have good performance, convenient operation and easy cleaning. Delicate, smooth and consistent quality ointment.
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