PHARMA: Three major characteristics of traditional Chinese medicine tablet press_Tablet Press_High Speed_Single Punch_Double Layer_Flower Basket Type_Multifunctional Rotary Tablet Press Machine

Three characteristics of traditional Chinese medicine tablet press technology
a Good fluidity: make powder operations such as flow filling go smoothly, reducing the difference in tablet weight;
b Good compression formability: no bad phenomena such as cracks;
C traditional Chinese medicine tablet press machine has good lubricity: the tablet is not sticky, and can make a complete and smooth tablet. Most pharmaceuticals require granulation prior to tablet compression. On the one hand, it meets the needs of the process, that is, it improves the fluidity and filling properties of the material to ensure a uniform dosage. On the other hand, it can greatly improve the compression formability, that is, the binder is evenly distributed on the surface of the particles, thereby changing the bonding force between the particles and changing the viscoelasticity of the material. In addition, an appropriate amount of water in the material is conducive to forming. Glidants added to formulations, such as micronized silica gel, can improve compressibility; lubricants, such as magnesium stearate, can reduce tablet strength but can also reduce tablet strength
Simplifying the process is one of the important measures of GMP standardization management. Although the process of direct powder compression is simple, the application of this method is limited due to the tendency of powder tablets to split and the poor flowability of the powder and the large variance in tablet weight. However, in recent years, with the development of functional new excipients and the application of modern equipment, powder compaction has become one of the hotspots in pharmaceutical research. Traditional Chinese medicine tablets refer to medicinal fine powders or extracts mixed with suitable excipients, processed and compressed into round or other forms of tablet-like sub-packages for internal or external use.
Tablets were developed according to the use of tablets. It was used in the 1840s. By the end of the 19th century, with the emergence and continuous improvement of traditional Chinese medicine tablet presses, the production and application of tablet presses had developed rapidly. In the past ten years, tablet production technology and mechanical equipment have been greatly developed, such as boiling granulation, traditional Chinese medicine tablet compression, semi-film coating, new auxiliary materials, new processes, and production linkages.
The research and production of traditional Chinese medicine tablets began in the 1950s. With the comprehensive research on the chemistry, preparation and clinical aspects of traditional Chinese medicine, the types and quantities of traditional Chinese medicine tablets are constantly increasing, the technical level is constantly improving, and the quality of the tablets is gradually improving. In addition to general compressed tablets and sugar-coated tablets, there are also microcapsules-buccal tablets-topical tablets and effervescent tablets.
In the tablet production process, a set of process conditions suitable for the production of traditional Chinese medicine tablets has been gradually explored, such as the preparation of tablets containing fatty oil and volatile oil, how to improve the hardness of traditional Chinese medicine tablets, improve disintegration, and tablet coating Gradually accumulate experience to continuously improve the quality.
In addition, research on the dissolution rate and bioavailability of drugs in traditional Chinese medicine tablets has been carried out step by step. In short, tablets have become one of many varieties, with high yield, wide range of uses, convenient use, storage and transportation, and stable quality preparations. Tablets account for more than 1/3 of the preparations contained in Chinese and many other national pharmacopoeias. can be seen in a wide range of applications.
The benefits of pressing Chinese medicine tablets with a tablet press are as follows:
① Generally speaking, the dissolution rate and bioavailability of tablets are better than those of pills;
②The dose of the tablet is accurate, and the difference in drug content is small;
③Quality-stable tablets are dry solids, and some drugs that are prone to oxidative degradation and deliquescence can be protected by coating. So light air and humidity have little effect on it.
④It is more convenient to carry and transport.
⑤ The mechanized production of traditional Chinese medicine tablet presses has a large output and low cost, and it is easy to meet the 'hygienic standard'.