Ointment production purification plant
Ointment production purification plant
Confirm before production in the ointment production purification plant, check whether the operation room, tools, containers, equipment, etc. have the clearance mark, and check whether it is within the validity period; check whether the preparation container and utensils are clean and dry, and use 75% ethanol if necessary Solution to emulsification tank, oil phase tank, preparation...
Text label: Cream production purification plant, cream clean plant, purification plant design and decoration
Ointment production purification plant
Confirm before production in the ointment production purification plant, check whether the operation room, tools, containers, equipment, etc. have the clearance mark, and check whether it is within the validity period; check whether the preparation container and utensils are clean and dry, and use 75% ethanol if necessary The solution sterilizes the emulsification tank, oil phase tank, preparation container and utensils; fills in the requisition list according to the production instructions, collects the raw materials and auxiliary materials from the material preparation and weighing clean room modular, and checks the product name, batch number, specification, quantity, and inspection report. Proceed to the next step; check whether the heating, stirring and vacuum are normal before operation, close the valves at the bottom of the oil phase tank and the emulsification tank, and open the cooling water valve of the vacuum pump.
The personnel enter the preparation room after the 'first shift' and 'second shiftwater, and cooled to 45°C with stirring. In the filling and sealing operation, the personnel enter the filling room after the 'first shift' and 'second shiftIn the upper hopper of the ointment filling and sealing machine, keep the temperature at about 34 °C and wait for filling; idle the ointment filling machine for a few minutes. After the trial operation is normal, insert the ointment tube to debug the filling volume of 10g/piece, and the filling volume can be determined. Filling; during the filling process, the filling quantity should be checked in time, and the appearance of the aluminum-plastic tube, whether there is leakage at the heat seal, whether the screw cap is tight, etc., should be checked at any time, and the inspection records should be made at the same time. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for ointment production purification plants and clean plants.
Quality requirements for ointment: the ointment should be uniform and delicate, without roughness when applied to the skin; it should have appropriate viscosity and be easy to apply to the skin or mucous membranes; it should be stable in nature, without rancidity, deterioration, etc. ; No irritation, allergic and other adverse reactions; the ointment used for the wound should also be sterile. The preparation of ointment generally adopts the grinding method and fusion method, and the cream adopts the emulsification method. The grinding method is mainly used for the preparation of semi-solid oleaginous bases and ointments that can be mixed at room temperature or are unstable to heat. The medicine and some bases or suitable liquids can be ground into a fine paste first, and then the rest of the bases can be added to grind until uniform. Take a small amount and apply it on the back of the hand until there is no particle feeling. In mass production, an electric mortar can be used. Melting method, where the melting point of the matrix in the ointment is not the same, such as a matrix containing a solid component with a higher melting point, it is necessary to use this method to melt the material with a higher melting point first, add the material with a lower melting point, and finally add the liquid component In order to avoid thermal decomposition of low melting point substances, usually the matrix is u200bu200bheated and melted, filtered, shaken and condensed, and a large amount of preparation can be mixed with an electric mixer.
The emulsification method is a method specially used for preparing creams. The oily and oil-soluble components in the formulation are heated and melted together, and used as the oil phase, the temperature of the oil phase is kept at about 80 °C, and the water-soluble components are dissolved in water, and heat it to the same temperature as the oil phase or slightly higher than the oil phase temperature, mix the oil and water, and keep stirring until the emulsification is completed and condensed into a paste; the components that are insoluble in oil and water are finally added. , Mix well, and if necessary, use a colloid mill to grind the cream when it is cooled to about 30°C to obtain a more delicate and uniform product.
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