How to reduce the sticking problem of tablet press_Tablet Press_High Speed_Single Punch_Double Punch_Flower Basket_Multifunctional Rotary Tablet Press PHARMA
The effervescent tablet contains sodium bicarbonate and organic acid, has effervescent effect when contacted with water, has the advantages of fast dissolution, fast drug effect, high bioavailability, convenient carrying, low cost and the like. However, since the excipients used in effervescent tablets are highly hygroscopic, the tablet machine is prone to sticking during tablet compression. How to solve the problem of sticking and sticking in the production process of effervescent tablets is one of the concerns of front-line technicians in pharmaceutical production.
First, choose a suitable acid source
Use a hygroscopic acid source such as citric acid, fumaric acid, or adipic acid instead of a hygroscopic acid source such as citric or malic acid. However, citric and malic acid taste good and sometimes require the use of oral effervescent tablets. Tartaric acid tends to become cloudy when it encounters calcium and magnesium ions. The water solubility of fumaric acid and adipic acid is not very good, the acidity is weak, the effervescence process is slow, and it is easy to leave a little residue on the surface of the solution after effervescence Disadvantages - effervescent tablet press machine.
Second, reduce the relative temperature and humidity
When using citric acid or malic acid as the acid source, the humidity should generally be controlled below 30%, and the temperature should be controlled at 18 to 20°C, especially for Chinese herbal extracts. When the temperature is high, dissolution may occur - effervescent tablet press
When drying, try to reduce the amount of water and keep the moisture below 1%. For direct compression, try excipients with better flow properties.