Crystallization equipment project in GMP workshop
Crystallization equipment project in GMP pharmaceutical cleanroom
The crystallization methods of GMP workshop include cooling, concentration, and changing solubility. Cooling is to reduce the temperature by air cooling, water cooling or ice brine cooling, etc. to make the solution supersaturated; The solubility of the solute decreases to reach overshoot and,...
Text label: GMP workshop, crystallization equipment engineering
GMP pharmaceutical cleanroom workshop crystallization equipment project
The crystallization methods of GMP workshop include cooling, concentration, and changing solubility. Cooling is to reduce the temperature by air cooling, water cooling or ice brine cooling, etc. to make the solution supersaturated; The solubility of the solute is reduced to achieve overshooting, or directly precipitate crystallization; concentrate the solution to evaporate under normal pressure or reduced pressure, increase the concentration of the solution, and make the solution supersaturated. Grain separation type cooling crystallizer, the feed liquid enters the crystallizer from the inlet pipe, reaches saturation in the cooler chamber through the circulating pipe, and the supersaturated solution enters the bottom of the crystallizer chamber through the circulating pump along the central pipeline. It is fully contacted with the suspended crystals to crystallize. The crystals of different sizes are separated at the bottom and the small ones are separated due to different sedimentation rates; At the bottom, it is discharged from the outlet pipe continuously or periodically.
Vacuum crystallizer adds hot saturated solution into a sealed crystallizer wrapped with adiabatic material, and maintains a certain degree of vacuum in the vessel. Due to the decrease of the boiling point of the solution, the solution is flashed in the vessel, and the adiabatic evaporation takes place in the vessel. The required heat can only be supplied by the adiabatic cooling of the solution, and the degree of cooling is determined by the degree of vacuum. For most systems where the solubility decreases with cooling, the crystallization yield increases due to the dual effects of evaporation and cooling. The crystallization process is often used in the production of raw materials, and there are certain requirements for the shape and particle size of the crystals. On the basis of ensuring the conditions of the purification equipment, it is very important to adopt a reasonable crystallization process. The effective means to increase the output is to recover the mother liquor, make full use of it after proper treatment. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for GMP workshops and clean workshops.
Controlling the size of crystal particles, large supersaturation, rapid cooling, vigorous stirring and high crystallization temperature can obtain fine crystal particles, otherwise, larger crystal particles will be obtained. The method of adding appropriate amount of crystal can not only control The size of the crystalline particles, and can control the crystal shape. The equipment used in the distillation operation in the GMP workshop is usually composed of a still and a distillation column. The structure of the still is the same as that of the evaporator, and is installed outside the rectifying column or directly below the rectifying column. Common rectifying columns include packing column and Tray towers include: bubble cap towers, sieve tray towers and valve towers, all of which are gas-liquid mass transfer equipment, and are also widely used in absorption, extraction and other operations.
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