10,000-level microbial clean room design requirements reference

The design of 10,000-level microbial clean room requires the reference design to be carried out on the basis of the civil engineering drawings and bidding instructions provided by the builder, in accordance with the 'Technical Specifications for Biosafety Buildings' GB50346-2004 and 'General Requirements for Biosafety' GB19489-2004 , 'General Guidelines for Biosafety of Microbial and Biomedical Laboratories' WS233-2002, 'Code for Design of pharmaceutical cleanroom' GB50073-2001, 'Code for Construction and Acceptance of Clean Room' JGJ71-90, 'Code for Construction and Quality Acceptance of Ventilation and Air Conditioning Engineering' , 'Ventilation and Air Conditioning of Construction and Installation Engineering Technical Operation Regulations', 'Code for Acceptance of Construction Quality of Building Water Supply and Drainage and Heating Engineering', 'Code for Electrical Design of Civil Buildings' and other relevant regulations, the architectural characteristics of the laboratory site have been carefully studied. After the analysis, based on the design concept of people-oriented, convenient experimental operation, and biosafety, the scheme design is completed under the premise of fully satisfying the plane layout provided by the experimental site. The design scheme should integrate security, high security, practicability and economy. 1. Plane layout (first-level barrier) design According to the site space provided by the experimental site, the microorganism experimental area is designed, taking the building area of ​​23m2 as an example. There should be a P2 main laboratory, a first buffer room, a second buffer room, and a washing and disinfection room. The design makes full use of the existing space, and carries out the layout according to the relevant national regulations and the special requirements of the experimental site. Considering the requirements that the biosafety laboratory should implement both the primary barrier and the secondary barrier, the primary barrier is mainly reflected in the layout and maintenance structure of the microbial experimental area, and the secondary barrier is mainly reflected in the air conditioning purification system. In terms of layout, the flow of people and logistics are separated to prevent cross-infection of people and objects: the experimental operators enter the P2 main laboratory through the first buffer room and the second buffer room; the experimental objects enter and exit through two interlocking transfer windows In the P2 main laboratory, one of the interlocking transfer windows is located between the main laboratory and the preparation room, and the other is located between the main laboratory and the scrubbing and disinfection room to ensure that the clean objects are not infected, and contaminants are also guaranteed. Transfer it to the scrubbing and disinfection room as soon as possible for disinfection and sterilization. The entire plane layout can fully meet the national norms and standards and the final requirements of the experimental site, and make full use of the building space divided by the experimental site. The floor size of each laboratory is assigned according to various experimental functions. 2. In the design of the enclosure structure and decoration, the main frame of the laboratory is a color steel plate glass partition, the color is matte white, the color steel thickness is 0.426mm on each side, and the fire rating of the color steel rock wool sandwich panel is non-combustible; polystyrene The fire rating of color steel sandwich panel is flame retardant. The thickness of the partition glass is 5mm; R25mm aluminum alloy arc pressure line is used to prevent dust deposition; the inner side of all 2D connections uses R50mm aluminum alloy fillet, and the outer side of the exposed 2D connection lines uses R100mm aluminum alloy Alloy fillet connection; three-dimensional joint transition of color steel plate, and aluminum alloy groove aluminum connection between color steel plate and wall and ground. The ceiling material is also color steel plate. The indoor floor of the microbial zone adopts imported PVC material for seamless welding, which has the characteristics of high precision, strong resistance, good flatness and easy cleaning. The ground corner line is decorated with inner corner aluminum material, which is beautiful and tight. Through scientific design and careful construction, the overall pharma machinery will form a solid, seamless, smooth, beautiful, non-reflective, dust-free, rust-proof, moisture-proof, antibacterial, and sterile surface and inner shell in the laboratory. Thereby, the problems of air tightness and cleaning are solved. All materials are processed and formed in the factory according to the design drawings, and then transported to the site for quick assembly and installation. All indoor pharma machinery is embedded in the wall, so that the entire laboratory wall is smooth and seamless, preventing dust accumulation and facilitating cleaning and disinfection. 3. Basic configuration of microbiology laboratory In addition to solving the problem of air purification, the purification laboratory should provide as much convenience as possible for experimental work. Therefore, some excellent laboratory utensils should be considered in the design. 1. Interlocking transfer window: There are two transfer windows in the P2 laboratory. The safety of laboratory logistics is guaranteed. There are ultraviolet lamps in the interlocking transfer window. When the contaminated items are taken out of the laboratory, they are disinfected. The interlocking transfer window also ensures the isolation of outdoor and indoor air, which facilitates the transfer of items by the experimenter and reduces the entry and exit of the experimenter. The number of laboratory. The transfer window can be controlled both indoors and outdoors. 2. Automatic door closer: according to the requirements of national regulations,An automatic door closer is installed on the clean laboratory door. 3. Interlocking door: The main laboratory is equipped with a set of electronic interlocking with two interlocking doors. When one door is not closed, the other door will not be able to open, which will buffer the airflow entering the clean room. The lock door is also equipped with an emergency switch. When an accident occurs, pressing the emergency switch is convenient for laboratory personnel to escape from the scene as soon as possible. 4. Multi-function microcomputer controller: as the general control cabinet of the laboratory, including temperature and humidity adjustment and display, start-stop and start-stop sequence of air supply and exhaust fans, lighting switch, ultraviolet lamp control, etc. The temperature adjustment display screen can accurately display the temperature in the laboratory, and the adjustment is convenient and the temperature error is small.
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