The problem of tablet disintegration delay in tablet press1
2023-08-29
Sz Pharma
180
1 Effect of tablet pore state. The general disintegration medium is water or artificial gastric juice, which has little change in viscosity. Therefore, the four main factors affecting the penetration of the disintegration medium (moisture) into the tablet are capillary number (porosity), capillary pore size (pore size R), surface tension γ, and contact angle θ of the liquid. Factors that affect this are: (1) The compressibility of the raw material. Compressible materials tend to deform plastically when compressed. The porosity and pore diameter R of the tablet are small, so the amount of water penetration and the distance L are small, and the disintegration of the tablet is slow. Experiments show that,
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