Sterilization of eye drops in sterile workshop
Sterilization of eye drops in sterile pharmaceutical cleanroom
Boil sterilization is to heat the eye drops into boiling water for sterilization, usually 30-60min. If in the plateau area, due to the decrease of the boiling point of water, 10-20g/L sodium carbonate can be added to the water to Increasing the boiling point of water can also be solved by appropriately extending the sterilization time. Generally...
Text label: sterile pharmaceutical cleanroom, design, construction, installation and renovation, eye drops sterilization
Sterilization of eye drops in sterile pharmaceutical cleanroom
Boil sterilization is to heat the eye drops into boiling water for sterilization, usually 30-60min. If in the plateau area, due to the decrease of the boiling point of water, 10-20g/L sodium carbonate can be added to the water to Increasing the boiling point of water can also be solved by appropriately extending the sterilization time. Generally, the sterilization time can be extended by 20% per liter of 300m. Autoclave sterilization, the most commonly used is the horizontal autoclave sterilizer, which mainly consists of a pressure-resistant empty chamber, exhaust port, safety valve, pressure gauge and thermometer formed by sealing the box door or box cover. Steam, electric heating, etc.; horizontal autoclave sterilizers are all made of solid alloys, some with interlayers, and two pressure gauges are installed on the top to indicate the pressure of the steam interlayer and the pressure in the cabinet respectively, and the middle of the pressure gauges It is a temperature gauge, with an exhaust port at the bottom, a temperature gauge on the exhaust pipe, a sterilization car with a track in the cabinet, a movable wire grid frame on the car, and a pushable truck, which can The sterilization truck is pushed to the truck and sent to the place where the sterilized items are loaded and unloaded; saturated steam must be used; the air in the cabinet must be exhausted, otherwise the pressure indicated on the pressure gauge is the total of the steam and air in the cabinet. pressure, not pure steam pressure, and the temperature does not meet the sterilization requirements; after sterilization, the pressure gauge pointer must be used to drop to 0 for 10-15 minutes, and then open the cabinet door; in order to ensure the sterilization effect and prevent leakage, in Appropriate sterilization temperature indicators are commonly used in production.
Microwave sterilization is a method of killing microorganisms with the heat generated by microwave irradiation. The frequency of microwaves is higher than 300MHz or the wavelength is shorter than 1m. As the voltage changes direction according to the high bottle rate colloid, the direction of the electric field also changes alternately, and the polarized molecules rotate continuously. As a result, part of the energy is converted into the energy of thermal motion, the molecular motion is intensified, and the molecules rub against each other to generate heat. , to increase the temperature of the material, which is characterized by energy saving, no environmental pollution, easy maintenance and simple operation. Ozone is a broad-spectrum sterilant that can sterilize bacterial propagules and spores. Ozone mainly relies on its strong oxidation for sterilization. The sterilization speed of ozone in water is 600-3000 times faster than that of chlorine, and ozone is used for air disinfection. , the relative humidity is high, the effect is good, otherwise the effect is poor. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for sterile workshops and sterile workshops.
Dry heat sterilization is a method of using dry hot air or flame to solidify the bacterial protoplasm and destroy the bacterial enzyme system to kill the bacteria. It is mostly used for the sterilization of containers and utensils. Dry hot air sterilization uses heat radiation and air convection in the sterilizer to transfer heat, so that the propagules of bacteria stop moving due to dehydration in the body. Due to the weak and uneven penetration of dry hot air, small specific heat, and thermal conductivity It needs a long time and high temperature to achieve the purpose of sterilization, generally 135-145 ℃ 3-5H, 160-170 ℃ 2-4H, 180-200 ℃ 0.5-1H; this method is suitable for high temperature resistant glass , metal and other utensils, as well as greases and high temperature resistant powders that do not allow moisture to penetrate, injection container ampoules, infusion bottles, glass bottles for eye drops and dry hot air for injection sterilization; commonly used equipment is electric heating box There are two types of air convection and forced air convection. The latter is equipped with a blower to circulate hot air around the sterilized items, which can shorten the time for all the sterilized items to reach the required temperature, and reduce the temperature difference between parts in the oven.
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