Sterilization of clean workshop
Sterilization of clean workshop
The sterilization methods of clean pharmaceutical cleanroom are divided into three categories: physical sterilization, chemical sterilization and aseptic operation. Physical sterilization is a method of killing microorganisms by using high temperature or other methods, such as filtration sterilization, ultraviolet lamps, etc.;
Text label: clean workshop sterilization, clean workshop sterilization, clean pharmaceutical cleanroom design and decoration
Clean workshop workshop sterilization
The sterilization methods of clean workshop are divided into three categories: physical sterilization, chemical sterilization and aseptic operation. Physical sterilization is a method of killing microorganisms by using high temperature or other methods, such as filter sterilization, ultraviolet lamps, etc.; The method of killing bacteria; a method of using heat radiation and convection of air in the sterilizer to transfer heat to make the propagules of bacteria stop moving due to dehydration in the body. Because the penetration of hot air is weak and uneven, The specific heat is small and the thermal conductivity is poor, so it takes a long time and high temperature to achieve the purpose of sterilization. Moist heat sterilization is the use of saturated steam or boiling water to kill microorganisms, including autoclaving, circulating steam sterilization, and boiling sterilization. The method of killing microorganisms with saturated steam at normal pressure has the advantages of complete and reliable sterilization, good effect, short time and easy control, and is suitable for infusion sterilization.
Generally, the time required for sterilization is inversely proportional to the temperature, that is, the higher the temperature, the shorter the time, but the higher the temperature, the faster the chemical reaction speed, the longer the time, the more the reacting substances; Under the premise of bacteria, the sterilization temperature should be reduced as much as possible or the sterilization time should be shortened; saturated steam has high heat content, large penetrating power, high sterilization effect, low heat content of wet saturated steam, superheated steam and dry water. Hot air is similar, their penetrating power is poor, and the sterilization effect is not good. Ultraviolet sterilization is the use of ultraviolet radiation to kill microorganisms. Generally, ultraviolet rays with a wavelength of 200-300nm can be used for sterilization. The wavelength with the strongest sterilization power is 254nm. The surface of the UV lamp cannot penetrate into the solution or the deep part of the solid, so it is only suitable for air and surface sterilization in the sterile room; UV lamps of different specifications have a fixed service period, generally 3000h, so the opening time should be recorded and checked regularly. Sterilization effect. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for clean workshops and clean workshops.
Operators should wash their hands, faces and wrists before entering the operating room, put on sterilized work clothes and special shoes, caps, masks, etc., do not expose hair, underwear, etc., cut off their nails, and follow the prescribed methods on both hands Wash and sterilize; the containers and utensils used should be sterilized by autoclaving or dry hot air sterilization. The indoor operators should not be too many, and the flow of personnel should be minimized. Most of the injections prepared by aseptic operation should be inhibited. Bacterial agent.
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