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Specific operation analysis of tablet weight out-of-tolerance problem in tablet press1

2023-10-03

Sz Pharma

157

The particle size distribution is uneven, and the flow rate of the particles is different during tablet compression, resulting in uneven particle size filled into the middle die hole. For example, a high amount of coarse particles will make the tablet lighter, and a higher amount of fine particles will make the tablet heavier. Processing method: Mix the granules evenly or sieve to remove excessive fine powder. If the fine powder adheres to the punch to form a hanging punch, the film weight may vary greatly. Solution: At this time, the rotation of the lower punch is not sensitive, it should be reflected in time, take out the punch, and clean the lower punch and the middle die hole.

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