Preparation of water for injection in sterile workshop
Preparation of water for injection in sterile workshop
Water for injection is prepared by distillation method. Purified water is used as raw water. The water obtained after condensing and cooling is distilled in a specially designed distiller. Water for injection can be used as a solvent for preparing eye drops to ensure eye drops. the quality of. In order to improve the quality of water for injection, the...
Text label: Preparation of water for injection in sterile workshop, pure water equipment in clean workshop
Preparation of water for injection in sterile workshop
Water for injection is prepared by distillation method. Purified water is used as raw water. The water obtained after condensing and cooling is distilled in a specially designed distiller. Water for injection can be used as a solvent for preparing eye drops to ensure eye drops. the quality of. In order to improve the quality of water for injection, a comprehensive method is generally used to prepare purified water and water for injection. Ion exchange resin method: tap water→multi-media filter→cation resin bed→anion resin bed→mixed resin bed→filter membrane→multi-effect distilled water device or vapor pressure distilled water device→hot water storage 80℃→water for injection. Reverse osmosis-ion exchange resin method: tap water→multi-media filter→filter membrane→reverse osmosis device→cation resin bed→anion resin bed→mixed resin bed→filter membrane→sterilization→water storage bucket→multi-effect distilled water device or steam pressure distilled water → Hot water reservoir 80°C → Water for injection.
There are many types of stills for preparing water for injection, but the basic structure is the same. They are composed of three parts: vaporization, foam isolation and condensation. The vaporization part is used to heat the container for producing steam, and the foam isolation device is used to block and remove the entrainment in the steam. The mist-like droplets, the condensation part is a device that uses cooling to turn the vapor into a liquid. The multi-effect distilled water device has the characteristics of good water quality, high output and energy saving. The distillation column can be three-effect, four-effect or five-effect. The main structure is composed of a cylindrical distillation column, a condenser and some control elements; The performance depends on the pressure and effect of the heating steam. The higher the pressure, the higher the output, the more the effect, and the higher the heat utilization rate. Considering factors such as water quality, energy consumption, and maintenance, choose a distilled water device with four or more effects. more reasonable. The steam pressure type distiller is to make the purified water flow into the water inlet at a pressure of 0.2-0.3MPa, after preheating through the heat exchanger, it is pumped into the evaporative condenser, and the water level in the tube is adjusted by the hydraulic regulator. The lower part of the condenser is equipped with a steam heating tube and an electric heater, both of which are used as auxiliary heating. The vapor pressure distilled water device has the advantages of the multi-effect distilled water device, but the power consumption is relatively large. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for sterile workshops and clean workshops.
Sterile water for injection in sterile pharmaceutical cleanroom is the water prepared according to the production process of injections. Sterile water for injection is used in ophthalmic preparations for the following aspects: ophthalmic powder, granule, block or tablet packaging as a standby solvent, For the preparation of eye drops before use; for the washing of equipment such as solvents and filters for the preparation of eye drops by aseptic operation; the preparation of ophthalmic injections. Pharmaceutical water is easily transported by stainless steel pumps that are easy to disassemble, clean and sterilize. In the case of purified water and water for injection that need to be delivered by compressed air or nitrogen pressure, the compressed air and nitrogen must be purified; purified water should be transported by circulating pipelines. The road design should be simple and blind pipes should be avoided. The pipeline should be made of stainless steel pipes or other pipes that are corrosion-resistant and do not seep out polluting ions. The valves are easy to use sanitary valves. Pipelines and delivery pumps should be cleaned and sterilized regularly, and they can be put into use only after they have passed the verification. The material for storing water for injection must be high-quality low-carbon stainless steel or other materials that have been verified to not pollute the water quality. The storage of water for injection can be stored at a temperature above 70 °C with a heat preservation cycle or below 4 °C. For hydrophobic sterilizing filters, the design and installation of piping should avoid dead pipes.
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