Oral liquid purification plant process and packaging
Oral liquid purification plant process and packaging
The general process for the preparation of oral liquid in the purification plant is: dosing → filtration → potting → sterilization → leak detection → labeling → boxing and other steps; in order to prevent the oral liquid from mildew during storage, appropriate preservatives, and are sterilized during the preparation process, sealed and packaged,...
Text label: Oral liquid purification plant, process and packaging
Oral liquid purification plant process and packaging
The general process for the preparation of oral liquid in the purification plant is: dosing → filtration → potting → sterilization → leak detection → labeling → boxing and other steps; in order to prevent the oral liquid from mildew during storage, appropriate In addition, the packaging container also needs to be cleaned, and contamination should be strictly prevented during the filling process; the raw and auxiliary materials used in the preparation of oral liquid should be strictly inspected according to quality standards, and qualified To be able to use, select appropriate additives, use prepared liquid dispensing equipment, and dispense liquid in strict accordance with the procedure; first, the packaging should be washed, dried, and sterilized, and then filled into vials according to the preparation process of injection.
Extraction: To extract active ingredients, the selected process should be reasonable, which can not only remove most of the impurities to reduce the volume, but also extract and retain the active ingredients as much as possible to ensure the curative effect. Preparation: The raw and auxiliary materials used in oral liquid should be inspected strictly according to the quality standards. Only qualified ones can be used. Appropriate additives should be selected. Filtration and refining: In the process of extraction and compounding, due to various foreign matters brought in by various factors, resins, pigments, coagulants and colloids contained in the extraction liquid need to be filtered out, and then fine filtration is carried out to remove particles and bacteria. Potting: After washing, drying, and sterilizing the package, the medicine is potted into the vial according to the preparation process of the injection. Sterilization: Sterilize the filled bottled oral liquid to eliminate microorganisms in the packaging and the pharmaceutical industry to ensure stability; regardless of whether the packaging is sterilized in the previous process, as long as the pharmaceutical industry fails to strictly sterilize the packaging sterilization of the bottled products; the sterilization methods include physical sterilization, microwave sterilization and radiation sterilization, and one or more methods can be used for combined sterilization as needed. The most common The most common is physical sterilization, of which more thermal sterilization is used. Leak detection, labeling, and boxing: The packaged bottled products need to be tested by vacuum leak detection and foreign body light inspection. After passing the inspection, a label is attached, the batch number and expiration date are printed, and finally boxed and packaged. Zhongjing Global Purification can provide consulting, planning, design, construction, installation, transformation and other supporting services for oral liquid purification plants and sterile workshops.
The packaging materials of oral liquid in purification plant include: ampoule bottle packaging, plastic bottle packaging, straight mouth bottle packaging, screw mouth bottle; The small grinding wheel cuts off the bottleneck, and it is easy for the glass debris to fall into the oral liquid; the plastic bottle packaging cost is low and it is convenient to take, but due to the high air permeability and moisture permeability of plastic, the product is not easy to sterilize, which has a negative impact on the production environment and packaging materials. The cleanliness requirements are very high; the screw-top bottle is developed on the basis of the straight-mouth bottle, which overcomes the hidden danger of lax capping, and structurally cancels the unsealing form of the tear bag
, and can be made into the form of an anti-theft cover, but the manufacturing is relatively complicated and the cost is high.
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