Differences in drug density affect the use of tablet presses
Master some maintenance plans of the tablet press to ensure that the equipment has a long service life. The following is an explanation by the editor. The amount of binder or wetting agent is insufficient or improperly selected, so that the particle texture is loose or the particle size distribution is uneven, and the coarse and fine particles are stratified. It can be overcome by choosing an appropriate binder or increasing the dosage, improving the granulation process, mixing more soft materials, and mixing granules. If the water content of the granules is too small, the over-dried granules have greater elasticity, and the drug containing crystal water loses more crystal water during the drying process of the granules, making the granules brittle and easy to loosen. Therefore in granulation
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