Animal isolation equipment for sterile biological laboratories
Animal isolation equipment for sterile biological laboratories
I. Overview:
The animal isolation equipment in the sterile biological laboratory can be divided into two categories: positive pressure experimental animal isolation device and negative pressure experimental animal isolation device according to the positive and negative static pressure difference in the cavity. Positive pressure laboratory animal isolation device refers to the internal...
Text label: sterile biological laboratory, sterile laboratory, biological laboratory, laboratory animal isolation equipment
Animal Isolation Equipment for Sterile Biological
I. Overview:
The animal isolation equipment in the sterile biological laboratory can be divided into two categories: positive pressure experimental animal isolation device and negative pressure experimental animal isolation device according to the positive and negative static pressure difference in the cavity. Positive pressure laboratory animal isolation device refers to the laboratory animal isolation device with positive pressure inside relative to the external environment; negative pressure pharma machinery animal isolation device refers to the laboratory animal isolation device with negative pressure inside relative to the external environment. Negative pressure isolators are mainly used in sterile biosafety laboratories. Usually, high-grade sterile biosafety laboratories are equipped with negative pressure animal isolators for animal feeding and experiments.
The animal isolation equipment in the sterile biological laboratory can be divided into two categories according to the degree of cavity sealing, the non-airtight laboratory animal isolation device and the airtight laboratory animal isolation device. The non-airtight laboratory animal isolation device refers to a laboratory animal isolation device with a non-hermetic enclosure structure in the state of closed air supply and exhaust ports. The air-tight laboratory animal isolation device refers to the laboratory animal isolation device whose enclosure structure is a closed structure and meets the relevant air-tight performance requirements when the air supply and exhaust ports are closed. Zhongjing Global Purification can provide consulting, planning, design, construction, installation and transformation of GMP workshops, clean workshops, sterile laboratories and other supporting services.
The difference between the non-airtight laboratory animal isolator and the airtight laboratory animal isolator mainly lies in the equipment structure and airtightness requirements, as detailed in the table.
The main difference between non-airtight pharma machinery animal isolator and airtight laboratory animal isolator
Protection performance classification
Equipment structure
way
Air tightness requirements
Non-air-tight
Open or semi-open (can be opened during operation)
Can not be connected to the device, can use local spray
No air tightness requirement
Airtight
Totally enclosed (glove box type or half helmet type), must be operated through the sleeve
Connect directly to the equipment for in-situ overall disinfection
Meet the airtightness requirements of Class II or Class III airtight chambers specified in 'Classification of Sealed Chambers and Test Methods' EJ/T1096 (equivalent to ISO40648)
Animal isolation equipment can be divided into animal breeding isolators and animal surgery isolators according to their uses; animal isolators can be divided into chicken isolators, pig isolators, monkey isolators, rabbit isolators, Rodent isolator animals, etc.; according to the classification of animal microbiology, the isolator can be divided into SPF (specific pathogen-free) grade isolator and GF (sterile) grade isolator: according to the material classification, the isolator can be divided into metal (stainless steel) grade isolator , aluminum alloy, etc.) isolator, glass fiber reinforced plastic (made of glass fiber and polymer resin) isolator, plastic isolator.
2. Problems that should be paid attention to in the design of sterile biological laboratory
The issues that should be paid attention to in the laboratory design of animal isolation equipment are similar to those of biological safety cabinets, that is, on-site installation location, reserved exhaust interface and other issues. For on-site installation location requirements, please refer to the installation location requirements of biological safety cabinets, and the installation location should be on the side of the air outlet. The exhaust connection method of animal isolation equipment is generally the external exhaust air duct method, and attention should be paid to the air tightness of the pipe after the animal isolation equipment is exhausted (soft connection).
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